Very-high-risk ALL criteria (evaluable cytogenetics; POG 1986 to 1999 and CCG 1988 to 1995)
| Group and NCI risk group . | No. patients . | 5-y EFS (SE) . | 8-y EFS (SE) . | |||
|---|---|---|---|---|---|---|
| POG . | CCG . | POG . | CCG . | POG . | CCG . | |
| All eligible* | 5056 | 1182 | 73.0 (0.8) | 76.0 (1.3) | 70.3 (1.1) | 74.2 (1.6) |
| Ph-positive | ||||||
| Any | 132‡ | 30 | 27.4 (4.4) | 33.3 (9.1) | 23.4 (5.5) | 28.6 (24.1) |
| Standard | 36 | 7 | 52.4 (8.8) | 28.6 (17.1) | 52.4 (11.4) | ND |
| High | 96 | 23 | 18.2 (5.0) | 34.8 (10.6) | 10.4 (4.9) | 29.0 (24.4) |
| Fewer than 45 chromosomes | ||||||
| Any | 58 | 14 | 46.5 (7.2) | 35.7 (12.8) | 46.5 (9.8) | 23.8 (14.7) |
| Standard | 27 | 6 | 44.4 (9.6) | 33.3 (19.3) | 44.4 (12.5) | 33.3 (27.2) |
| High | 31 | 8 | 48.2 (11.0) | 37.5 (17.1) | 48.2 (15.5) | 18.8 (16.9) |
| Other† | ||||||
| Any | 4866§ | 1138 | 74.6 (0.8) | 77.7 (1.3) | 71.9 (1.1) | 76.0 (1.8) |
| Standard | 3453 | 763 | 79.3 (0.8) | 80.4 (1.5) | 77.1 (1.2) | 79.0 (2.1) |
| High | 1402 | 375 | 63.1 (1.6) | 71.9 (2.4) | 58.8 (2.3) | 69.9 (3.5) |
| Group and NCI risk group . | No. patients . | 5-y EFS (SE) . | 8-y EFS (SE) . | |||
|---|---|---|---|---|---|---|
| POG . | CCG . | POG . | CCG . | POG . | CCG . | |
| All eligible* | 5056 | 1182 | 73.0 (0.8) | 76.0 (1.3) | 70.3 (1.1) | 74.2 (1.6) |
| Ph-positive | ||||||
| Any | 132‡ | 30 | 27.4 (4.4) | 33.3 (9.1) | 23.4 (5.5) | 28.6 (24.1) |
| Standard | 36 | 7 | 52.4 (8.8) | 28.6 (17.1) | 52.4 (11.4) | ND |
| High | 96 | 23 | 18.2 (5.0) | 34.8 (10.6) | 10.4 (4.9) | 29.0 (24.4) |
| Fewer than 45 chromosomes | ||||||
| Any | 58 | 14 | 46.5 (7.2) | 35.7 (12.8) | 46.5 (9.8) | 23.8 (14.7) |
| Standard | 27 | 6 | 44.4 (9.6) | 33.3 (19.3) | 44.4 (12.5) | 33.3 (27.2) |
| High | 31 | 8 | 48.2 (11.0) | 37.5 (17.1) | 48.2 (15.5) | 18.8 (16.9) |
| Other† | ||||||
| Any | 4866§ | 1138 | 74.6 (0.8) | 77.7 (1.3) | 71.9 (1.1) | 76.0 (1.8) |
| Standard | 3453 | 763 | 79.3 (0.8) | 80.4 (1.5) | 77.1 (1.2) | 79.0 (2.1) |
| High | 1402 | 375 | 63.1 (1.6) | 71.9 (2.4) | 58.8 (2.3) | 69.9 (3.5) |
ND indicates not done.
Includes all patients with evaluable immunophenotyping and evaluable cytogenetics.
Those with evaluable cytogenetics that do not have traits listed above it for those risk groups.
Six Ph-positive patients had fewer than 45 chromosomes and are excluded from the “fewer than 45 chromosomes” group.
Eleven of the 4866 POG patients could not be classified into an NCI risk group due to missing WBC count at diagnosis and hence were included only in the overall (“Any”) analyses.