Table 1 CD70 expression on... | American Society of Hematology

Table 1

CD70 expression on representative tumor cell lines

Cancer type	Frequency of CD70 expression, no. CD70⁺ cell lines/total no. cell lines*	Range of receptor copy no.†	Representative cell line (receptor no.)
Non-Hodgkin lymphoma	16/19	1 200-120 000	IM-9 (120 000), Raji (23 000), Farage (31 000), WIL2-S (52 000), MHH-PREB-1 (28 000)
Hodgkin disease	7/9	11 000-220 000	L428 (120 000)
Multiple myeloma	9/14	9 000-150 000	U266 (150 000), LP-1 (64 000)
Renal cell carcinoma	13/14	2 400-420 000	786-O (160 000), Caki-1 (140 000)

Cancer type	Frequency of CD70 expression, no. CD70⁺ cell lines/total no. cell lines*	Range of receptor copy no.†	Representative cell line (receptor no.)
Non-Hodgkin lymphoma	16/19	1 200-120 000	IM-9 (120 000), Raji (23 000), Farage (31 000), WIL2-S (52 000), MHH-PREB-1 (28 000)
Hodgkin disease	7/9	11 000-220 000	L428 (120 000)
Multiple myeloma	9/14	9 000-150 000	U266 (150 000), LP-1 (64 000)
Renal cell carcinoma	13/14	2 400-420 000	786-O (160 000), Caki-1 (140 000)

Cell lines expressing greater than 1000 receptors or exhibiting at least 2.5-fold mean fluorescence intensity above that of nonbinding isotype control were considered as positive for CD70.

†

Receptor copy number was determined by quantitative flow cytometry as described in “Materials and methods.”

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