Table 3

Genes differentially expressed in CD4+CD56+HN versus c-AML

Fold changeDescriptionGene symbolDistribution of expression according to GNF SymAtlas
BDCA4+ dendritic cellsCentral nervous systemBM CD33+ myeloid cells
    449.97 T-cell leukemia/lymphoma 1A TCL1A* X   
    255.10 Immunoglobulin lambda-like polypeptide 1 IGLL1    
    138.92 Sodium channel, voltage-gated, type III, alpha SCN3A*  X  
    109.07 B-cell novel protein 1 BCNP1* X   
    69.38 Spi-B transcription factor (Spi-1/PU.1 related) SPIB X   
    37.01 Hairy and enhancer of split 6 (Drosophila) HES6*    
    35.20 Serine hydrolase-like 2 SERHL2  X  
    34.48 Hypothetical protein FLJ20716 FLJ20716  X  
    29.86 Cyclic AMP-regulated phosphoprotein, 21 kDa ARPP-21  X  
    29.00 RAS, dexamethasone-induced 1 RASD1 X X  
    28.85 Sidekick homolog 2 (chicken) SDK2  X  
    28.64 Proapoptotic caspase adaptor protein PACAP* X   
    25.91 Chromosome 14 open reading frame 175 C14orf175 NA NA NA 
    24.61 Fc receptor homolog expressed in B cells FREB X   
    24.25 Deoxynucleotidyltransferase, terminal TdT    
23.56 Sialic acid binding Ig-like lectin 6 (CD33-like1) SIGLEC6*    
    23.33 WAS protein family, member 1 WASF1*  X  
    21.96 Thymosin-like 8 TMSL8  X  
    21.07 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 PFKFB2 X   
    20.69 Interleukin-28 receptor, alpha (interferon, lambda receptor) IL28RA    
    20.32 Hypothetical protein LOC158402 LOC158402 NA NA NA 
    19.56 KIAA0746 protein KIAA0746 X   
    19.21 B-cell linker BLNK X   
    19.13 Potassium channel, subfamily K, member 17 KCNK17 X   
    18.96 Protein tyrosine phosphatase, receptor type, S PTPRS X   
    18.64 G protein-coupled receptor 160 GPR160*    
    18.14 Napsin B aspartic peptidase pseudogene NAPSB X   
    18.08 Brain expressed X-linked 2 BEX2  X  
    17.77 Troponin I, skeletal, fast TNNI2    
17.20 Runt-related transcription factor 2 RUNX2*    
    16.23 Hypothetical LOC339541 MGC33556 X   
    16.08 Chromosome 18 open reading frame 1 C18orf1  X  
    15.96 Serine hydrolase-like SERHL  X  
    15.91 B-cell CLL/lymphoma 11A (zinc finger protein) BCL11A X   
    15.47 Immunoglobulin J polypeptide IGJ X   
    14.75 Core-binding factor, runt domain, alpha subunit 2; transl. 3 CBFA2T3* X   
    14.69 Adenosine deaminase ADA X   
    14.02 T-cell receptor alpha locus /// T-cell receptor delta locus TRA /// TRD X   
    13.71 Myosin VI MYO6  X  
    13.41 PDZ domain containing RING finger 3 PDZRN3  X  
    12.97 Solute carrier family 38, member 1 SLC38A1 X   
    12.06 Fas apoptotic inhibitory molecule FAIM3 X   
    11.98 Selectin L (lymphocyte adhesion molecule 1) SELL X   
    11.06 Chromosome 3 open reading frame 6 C3orf6 X   
    11.05 UDP-glucose ceramide glucosyltransferase UGCG* X   
    10.42 SRY (sex determining region Y)-box 4 SOX4 X   
    10.00 Protein phosphatase 1K (PP2C domain containing) PPM1K X   
    0.02 C-type lectin domain family 5, member A CLEC5A*   X 
    0.03 Myeloid-cell nuclear differentiation antigen MNDA   X 
    0.04 C-type lectin domain family 7, member A CLEC7A   X 
    0.04 Regulator of G-protein signaling 18 RGS18   X 
    0.04 Hypothetical protein FLJ33069 FLJ33069   X 
    0.05 V-set and immunoglobulin domain containing 4 VSIG4    
    0.05 Chemokine (C-X3-C motif) receptor 1 CX3CR1    
    0.05 Ficolin (collagen/fibrinogen domain containing) 1 FCN1   X 
    0.05 Cathepsin G CTSG    
    0.06 CD33 antigen (gp67) CD33*   X 
    0.06 Calcium channel, voltage-dependent, alpha 2/delta subunit 4 CACNA2D4    
    0.06 Fc fragment of IgG, high affinity Ia, receptor (CD64) FCGR1A   X 
    0.08 Toll-like receptor 8 TLR8   X 
    0.08 Complement component 3a receptor 1 C3AR1   X 
    0.09 Potassium voltage-gated channel, Isk-related family, member 3 KCNE3   X 
    0.10 CD14 antigen CD14   X 
Fold changeDescriptionGene symbolDistribution of expression according to GNF SymAtlas
BDCA4+ dendritic cellsCentral nervous systemBM CD33+ myeloid cells
    449.97 T-cell leukemia/lymphoma 1A TCL1A* X   
    255.10 Immunoglobulin lambda-like polypeptide 1 IGLL1    
    138.92 Sodium channel, voltage-gated, type III, alpha SCN3A*  X  
    109.07 B-cell novel protein 1 BCNP1* X   
    69.38 Spi-B transcription factor (Spi-1/PU.1 related) SPIB X   
    37.01 Hairy and enhancer of split 6 (Drosophila) HES6*    
    35.20 Serine hydrolase-like 2 SERHL2  X  
    34.48 Hypothetical protein FLJ20716 FLJ20716  X  
    29.86 Cyclic AMP-regulated phosphoprotein, 21 kDa ARPP-21  X  
    29.00 RAS, dexamethasone-induced 1 RASD1 X X  
    28.85 Sidekick homolog 2 (chicken) SDK2  X  
    28.64 Proapoptotic caspase adaptor protein PACAP* X   
    25.91 Chromosome 14 open reading frame 175 C14orf175 NA NA NA 
    24.61 Fc receptor homolog expressed in B cells FREB X   
    24.25 Deoxynucleotidyltransferase, terminal TdT    
23.56 Sialic acid binding Ig-like lectin 6 (CD33-like1) SIGLEC6*    
    23.33 WAS protein family, member 1 WASF1*  X  
    21.96 Thymosin-like 8 TMSL8  X  
    21.07 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 PFKFB2 X   
    20.69 Interleukin-28 receptor, alpha (interferon, lambda receptor) IL28RA    
    20.32 Hypothetical protein LOC158402 LOC158402 NA NA NA 
    19.56 KIAA0746 protein KIAA0746 X   
    19.21 B-cell linker BLNK X   
    19.13 Potassium channel, subfamily K, member 17 KCNK17 X   
    18.96 Protein tyrosine phosphatase, receptor type, S PTPRS X   
    18.64 G protein-coupled receptor 160 GPR160*    
    18.14 Napsin B aspartic peptidase pseudogene NAPSB X   
    18.08 Brain expressed X-linked 2 BEX2  X  
    17.77 Troponin I, skeletal, fast TNNI2    
17.20 Runt-related transcription factor 2 RUNX2*    
    16.23 Hypothetical LOC339541 MGC33556 X   
    16.08 Chromosome 18 open reading frame 1 C18orf1  X  
    15.96 Serine hydrolase-like SERHL  X  
    15.91 B-cell CLL/lymphoma 11A (zinc finger protein) BCL11A X   
    15.47 Immunoglobulin J polypeptide IGJ X   
    14.75 Core-binding factor, runt domain, alpha subunit 2; transl. 3 CBFA2T3* X   
    14.69 Adenosine deaminase ADA X   
    14.02 T-cell receptor alpha locus /// T-cell receptor delta locus TRA /// TRD X   
    13.71 Myosin VI MYO6  X  
    13.41 PDZ domain containing RING finger 3 PDZRN3  X  
    12.97 Solute carrier family 38, member 1 SLC38A1 X   
    12.06 Fas apoptotic inhibitory molecule FAIM3 X   
    11.98 Selectin L (lymphocyte adhesion molecule 1) SELL X   
    11.06 Chromosome 3 open reading frame 6 C3orf6 X   
    11.05 UDP-glucose ceramide glucosyltransferase UGCG* X   
    10.42 SRY (sex determining region Y)-box 4 SOX4 X   
    10.00 Protein phosphatase 1K (PP2C domain containing) PPM1K X   
    0.02 C-type lectin domain family 5, member A CLEC5A*   X 
    0.03 Myeloid-cell nuclear differentiation antigen MNDA   X 
    0.04 C-type lectin domain family 7, member A CLEC7A   X 
    0.04 Regulator of G-protein signaling 18 RGS18   X 
    0.04 Hypothetical protein FLJ33069 FLJ33069   X 
    0.05 V-set and immunoglobulin domain containing 4 VSIG4    
    0.05 Chemokine (C-X3-C motif) receptor 1 CX3CR1    
    0.05 Ficolin (collagen/fibrinogen domain containing) 1 FCN1   X 
    0.05 Cathepsin G CTSG    
    0.06 CD33 antigen (gp67) CD33*   X 
    0.06 Calcium channel, voltage-dependent, alpha 2/delta subunit 4 CACNA2D4    
    0.06 Fc fragment of IgG, high affinity Ia, receptor (CD64) FCGR1A   X 
    0.08 Toll-like receptor 8 TLR8   X 
    0.08 Complement component 3a receptor 1 C3AR1   X 
    0.09 Potassium voltage-gated channel, Isk-related family, member 3 KCNE3   X 
    0.10 CD14 antigen CD14   X 

Genes differentially expressed in CD4+CD56+HN versus c-AML resulting from supervised analysis applying a fold change difference of at least 10. Expression distribution according to the Genomics Institute of the Novartis Research Foundation (GNF) SymAtlas is indicated (X). Bold indicates genes seemingly characteristic for CD4+CD56+HN (for details see “Putative oncogenes” and “Novel membrane-bound markers for CD4+CD56+HN”).

NA indicates not available.

*

Genes verified by real-time RT-PCR.

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