Gene sets enriched in MK-3 compared with all other isolated MK populations
| Gene set . | FDR . | Rank . |
|---|---|---|
| Signaling, cell motility, cytoskeleton | ||
| RAR up-regulation | 0.27 | 1 |
| SIG PIP3 signaling in B lymphocytes | 0.28 | 2 |
| Rac1 pathway | 0.20 | 3 |
| GLUCO | 0.18 | 5 |
| CR cytoskeleton | 0.17 | 6 |
| Insulin signaling | 0.14 | 10 |
| Ptdins pathway | 0.13 | 15 |
| mCalpain pathway | 0.13 | 16 |
| Cell motility | 0.13 | 19 |
| Egf pathway* | 0.14 | 29 |
| Ras pathway | 0.15 | 32 |
| Igf1 pathway | 0.15 | 33 |
| Rho pathway | 0.15 | 38 |
| Transcriptional regulation | ||
| CBFB MYH11 downing AML | 0.16 | 4 |
| HOXA9 down-regulation | 0.16 | 7 |
| Down-regulation by HOXA9 | 0.12 | 14 |
| Up-regulation of G1ER | 0.13 | 18 |
| MLL chimeric fusion downing AML | 0.13 | 20 |
| GATA1 WEISS | 0.13 | 21 |
| Calcineurin pathway | 0.14 | 31 |
| Pparα pathway | 0.16 | 45 |
| NFAT pathway | 0.15 | 46 |
| General cell properties | ||
| Bcl2 family and regulatory network | 0.15 | 9 |
| Bad pathway | 0.13 | 11 |
| Intrinsic pathway | 0.13 | 17 |
| Fatty acid metabolism | 0.12 | 22 |
| GO reactive O2 species | 0.12 | 23 |
| ST dictyostelium cAMP chemotaxis | 0.12 | 24 |
| NK-cell pathway | 0.14 | 30 |
| HL60 ATRA BEN | 0.15 | 34 |
| Parkin pathway | 0.14 | 35 |
| Gene set . | FDR . | Rank . |
|---|---|---|
| Signaling, cell motility, cytoskeleton | ||
| RAR up-regulation | 0.27 | 1 |
| SIG PIP3 signaling in B lymphocytes | 0.28 | 2 |
| Rac1 pathway | 0.20 | 3 |
| GLUCO | 0.18 | 5 |
| CR cytoskeleton | 0.17 | 6 |
| Insulin signaling | 0.14 | 10 |
| Ptdins pathway | 0.13 | 15 |
| mCalpain pathway | 0.13 | 16 |
| Cell motility | 0.13 | 19 |
| Egf pathway* | 0.14 | 29 |
| Ras pathway | 0.15 | 32 |
| Igf1 pathway | 0.15 | 33 |
| Rho pathway | 0.15 | 38 |
| Transcriptional regulation | ||
| CBFB MYH11 downing AML | 0.16 | 4 |
| HOXA9 down-regulation | 0.16 | 7 |
| Down-regulation by HOXA9 | 0.12 | 14 |
| Up-regulation of G1ER | 0.13 | 18 |
| MLL chimeric fusion downing AML | 0.13 | 20 |
| GATA1 WEISS | 0.13 | 21 |
| Calcineurin pathway | 0.14 | 31 |
| Pparα pathway | 0.16 | 45 |
| NFAT pathway | 0.15 | 46 |
| General cell properties | ||
| Bcl2 family and regulatory network | 0.15 | 9 |
| Bad pathway | 0.13 | 11 |
| Intrinsic pathway | 0.13 | 17 |
| Fatty acid metabolism | 0.12 | 22 |
| GO reactive O2 species | 0.12 | 23 |
| ST dictyostelium cAMP chemotaxis | 0.12 | 24 |
| NK-cell pathway | 0.14 | 30 |
| HL60 ATRA BEN | 0.15 | 34 |
| Parkin pathway | 0.14 | 35 |
Listed are 31 of the top 46 functional domains identified by GSEA as being enriched in MK-3.
FDR indicates false discovery rate; and AML, acute myeloid leukemia.
P = .05; P < .001 for all other gene sets.