Table 2.

Effect of EM011 on the cell cycle progression of CEM/VLB100 cells



CEM/VLB100 cells, %
Cell cycle phase
0 h
12 h
24 h
48 h
72 h
G0/G1  41.45 ± 3.63   18.33 ± 0.98   16.12 ± 0.99   11.80 ± 1.11   6.37 ± 0.86  
S   26.34 ± 1.89   17.93 ± 1.18   24.19 ± 1.44   12.32 ± 1.78   9.91 ± 1.37  
G2/M   33.29 ± 2.20   46.75 ± 2.22   24.73 ± 1.38   9.39 ± 0.88   6.41 ± 0.86  
Sub-G1
 
0.88 ± 0.10
 
17.81 ± 1.77
 
27.87 ± 2.20
 
63.47 ± 5.47
 
75.17 ± 6.32
 


CEM/VLB100 cells, %
Cell cycle phase
0 h
12 h
24 h
48 h
72 h
G0/G1  41.45 ± 3.63   18.33 ± 0.98   16.12 ± 0.99   11.80 ± 1.11   6.37 ± 0.86  
S   26.34 ± 1.89   17.93 ± 1.18   24.19 ± 1.44   12.32 ± 1.78   9.91 ± 1.37  
G2/M   33.29 ± 2.20   46.75 ± 2.22   24.73 ± 1.38   9.39 ± 0.88   6.41 ± 0.86  
Sub-G1
 
0.88 ± 0.10
 
17.81 ± 1.77
 
27.87 ± 2.20
 
63.47 ± 5.47
 
75.17 ± 6.32
 

Cells were treated with 10 μM EM011 for the indicated time (h) before being stained with Pl for cell cycle analysis. Values shown are mean ± SEM.

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