FBAT analysis of promoter haplotypes in CDKN2B, CDKN1A, and CDKN1B
| Gene and haplotype . | Frequency . | No. of families* . | Statistic† . | E(S)‡ . | Var(S)§ . | Z . | P . | χ2 (df) . | Global P . |
|---|---|---|---|---|---|---|---|---|---|
| CDKN2B | 8.0 (4) | .09 | |||||||
| CAC | .41 | 77.0 | 88.1 | 76.5 | 27.1 | 2.22 | .03 | ||
| CTG | .35 | 69.9 | 56.9 | 69.9 | 28.5 | −2.44 | .01 | ||
| CAG | .18 | 61.0 | 44.9 | 40.5 | 16.6 | 1.09 | .27 | ||
| TAG | .03 | 10.2 | 3.2 | 5.1 | 2.4 | −1.24 | .22 | ||
| CCG | .02 | 9.0 | — | — | — | — | — | ||
| TAC | .01 | 4.8 | — | — | — | — | — | ||
| CDKN1A | 3.9 (4) | .42 | |||||||
| TTT | .55 | 59.0 | 75 | 76.5 | 24.3 | −0.31 | .76 | ||
| CGC | .22 | 47.0 | 35.2 | 38.1 | 16.9 | −0.71 | .48 | ||
| CTC | .17 | 45.0 | 36.8 | 31.9 | 13.5 | 1.33 | .18 | ||
| TGC | .05 | 19.8 | 11.8 | 10.4 | 5.7 | 0.59 | .56 | ||
| TGT | .01 | 2.0 | — | — | — | — | — | ||
| CTT | .01 | 3.0 | — | — | — | — | — | ||
| CGT | .002 | 1.0 | — | — | — | — | — | ||
| CDKN1B | 5.9 (4) | .21 | |||||||
| CGT | .42 | 75.9 | 74.8 | 80.7 | 27.0 | −1.15 | .25 | ||
| CGG | .38 | 76.0 | 80.7 | 73.5 | 24.1 | 1.47 | .14 | ||
| CAG | .09 | 35.2 | 22.4 | 19.1 | 8.4 | 1.14 | .25 | ||
| TGG | .11 | 35.8 | 16.4 | 21.2 | 10.2 | −1.49 | .14 | ||
| TGT | .01 | 2.3 | — | — | — | — | — |
| Gene and haplotype . | Frequency . | No. of families* . | Statistic† . | E(S)‡ . | Var(S)§ . | Z . | P . | χ2 (df) . | Global P . |
|---|---|---|---|---|---|---|---|---|---|
| CDKN2B | 8.0 (4) | .09 | |||||||
| CAC | .41 | 77.0 | 88.1 | 76.5 | 27.1 | 2.22 | .03 | ||
| CTG | .35 | 69.9 | 56.9 | 69.9 | 28.5 | −2.44 | .01 | ||
| CAG | .18 | 61.0 | 44.9 | 40.5 | 16.6 | 1.09 | .27 | ||
| TAG | .03 | 10.2 | 3.2 | 5.1 | 2.4 | −1.24 | .22 | ||
| CCG | .02 | 9.0 | — | — | — | — | — | ||
| TAC | .01 | 4.8 | — | — | — | — | — | ||
| CDKN1A | 3.9 (4) | .42 | |||||||
| TTT | .55 | 59.0 | 75 | 76.5 | 24.3 | −0.31 | .76 | ||
| CGC | .22 | 47.0 | 35.2 | 38.1 | 16.9 | −0.71 | .48 | ||
| CTC | .17 | 45.0 | 36.8 | 31.9 | 13.5 | 1.33 | .18 | ||
| TGC | .05 | 19.8 | 11.8 | 10.4 | 5.7 | 0.59 | .56 | ||
| TGT | .01 | 2.0 | — | — | — | — | — | ||
| CTT | .01 | 3.0 | — | — | — | — | — | ||
| CGT | .002 | 1.0 | — | — | — | — | — | ||
| CDKN1B | 5.9 (4) | .21 | |||||||
| CGT | .42 | 75.9 | 74.8 | 80.7 | 27.0 | −1.15 | .25 | ||
| CGG | .38 | 76.0 | 80.7 | 73.5 | 24.1 | 1.47 | .14 | ||
| CAG | .09 | 35.2 | 22.4 | 19.1 | 8.4 | 1.14 | .25 | ||
| TGG | .11 | 35.8 | 16.4 | 21.2 | 10.2 | −1.49 | .14 | ||
| TGT | .01 | 2.3 | — | — | — | — | — |
Haplotype-specific FBAT analyses were performed under the additive model.
df indicates degrees of freedom; —, not applicable due to lack of informative families (ie, < 10).
Number of informative families (ie, families with at least 1 heterozygote parent).
Test statistic from FBAT for the observed number of transmitted alleles.
Expected value of S under the null hypothesis (ie, no linkage or association).
Variance of the test statistic S.