Distribution of CDKN2A, CDKN2B, CDKN1A, and CDKN1B promoter-based genotypes among childhood patients with pre-B ALL and controls
| Genes, DNA variant, and genotype . | No. (%) . | OR (95% CI) . | P . | |
|---|---|---|---|---|
| ALL patients . | Controls . | |||
| CDKN2A | ||||
| −222T>A | ||||
| TT | 195 (85.9) | 256 (93.1) | 1 (referent) | — |
| TA | 30 (13.2) | 18 (6.5) | 2.6 (1.1-4.3) | .01 |
| AA | 2 (0.9) | 1 (0.4) | 2.6 (0.1-155.5) | .58 |
| CDKN2B | ||||
| −1270C>T | ||||
| CC | 200 (91.3) | 260 (94.2) | 1 (referent) | — |
| CT | 18 (8.2) | 15 (5.4) | 1.6 (0.7-3.4) | .28 |
| TT | 1 (0.5) | 1 (0.4) | 1.3 (0.02-102.4) | .99 |
| −593A>T,C | ||||
| AA | 97 (44.7) | 98 (36.0) | 1 (referent) | — |
| AT | 86 (39.6) | 124 (45.6) | 0.7 (0.5-1.1) | .09 |
| TT | 23 (10.6) | 38 (14.0) | 0.6 (0.3-1.1) | .11 |
| AC | 9 (4.2) | 6 (2.2) | 1.5 (0.5-5.4) | .59 |
| CC | 0 (0) | 0 (0) | — | — |
| TC | 2 (0.9) | 6 (2.2) | 0.3 (0.03-2.0) | .28 |
| −287G>C | ||||
| GG | 73 (33.5) | 82 (30.0) | 1 (referent) | — |
| GC | 104 (47.7) | 145 (52.9) | 0.8 (0.5-1.2) | .30 |
| CC | 41 (18.8) | 47 (17.1) | 1.0 (0.6-1.7) | .99 |
| CDKN1A | ||||
| −1284T>C | ||||
| TT | 76 (37.8) | 110 (40.6) | 1 (referent) | — |
| TC | 97 (48.3) | 132 (48.7) | 1.1 (0.7-1.6) | .77 |
| CC | 28 (13.9) | 29 (10.7) | 1.4 (0.7-2.7) | .29 |
| −899T>G | ||||
| TT | 114 (57.9) | 149 (55.0) | 1 (referent) | — |
| TG | 70 (35.5) | 103 (38.0) | 0.9 (0.6-1.3) | .62 |
| GG | 13 (6.6) | 19 (7.0) | 0.9 (0.4-2.0) | .85 |
| −791T>C | ||||
| TT | 70 (34.8) | 99 (36.5) | 1 (referent) | — |
| TC | 97 (48.3) | 133 (49.1) | 1.0 (0.7-1.6) | .92 |
| CC | 34 (16.9) | 39 (14.4) | 1.2 (0.7-2.2) | .48 |
| CDKN1B | ||||
| −1857C>T | ||||
| CC | 166 (80.6) | 209 (79.5) | 1 (referent) | — |
| CT | 39 (18.9) | 52 (19.8) | 0.9 (0.6-1.5) | .91 |
| TT | 1 (0.5) | 2 (0.7) | 0.6 (0.01-12.2) | .99 |
| −1608G>A | ||||
| GG | 184 (78.6) | 231 (84.9) | 1 (referent) | — |
| GA | 50 (21.4) | 37 (13.6) | 1.7 (1.0-2.8) | .03 |
| AA | 0 (0) | 4 (1.5) | — | — |
| −373G>T | ||||
| GG | 77 (35.0) | 89 (32.1) | 1 (referent) | — |
| GT | 107 (48.6) | 138 (49.8) | 0.9 (0.6-1.4) | .61 |
| TT | 36 (16.4) | 50 (18.1) | 0.8 (0.5-1.5) | .51 |
| Genes, DNA variant, and genotype . | No. (%) . | OR (95% CI) . | P . | |
|---|---|---|---|---|
| ALL patients . | Controls . | |||
| CDKN2A | ||||
| −222T>A | ||||
| TT | 195 (85.9) | 256 (93.1) | 1 (referent) | — |
| TA | 30 (13.2) | 18 (6.5) | 2.6 (1.1-4.3) | .01 |
| AA | 2 (0.9) | 1 (0.4) | 2.6 (0.1-155.5) | .58 |
| CDKN2B | ||||
| −1270C>T | ||||
| CC | 200 (91.3) | 260 (94.2) | 1 (referent) | — |
| CT | 18 (8.2) | 15 (5.4) | 1.6 (0.7-3.4) | .28 |
| TT | 1 (0.5) | 1 (0.4) | 1.3 (0.02-102.4) | .99 |
| −593A>T,C | ||||
| AA | 97 (44.7) | 98 (36.0) | 1 (referent) | — |
| AT | 86 (39.6) | 124 (45.6) | 0.7 (0.5-1.1) | .09 |
| TT | 23 (10.6) | 38 (14.0) | 0.6 (0.3-1.1) | .11 |
| AC | 9 (4.2) | 6 (2.2) | 1.5 (0.5-5.4) | .59 |
| CC | 0 (0) | 0 (0) | — | — |
| TC | 2 (0.9) | 6 (2.2) | 0.3 (0.03-2.0) | .28 |
| −287G>C | ||||
| GG | 73 (33.5) | 82 (30.0) | 1 (referent) | — |
| GC | 104 (47.7) | 145 (52.9) | 0.8 (0.5-1.2) | .30 |
| CC | 41 (18.8) | 47 (17.1) | 1.0 (0.6-1.7) | .99 |
| CDKN1A | ||||
| −1284T>C | ||||
| TT | 76 (37.8) | 110 (40.6) | 1 (referent) | — |
| TC | 97 (48.3) | 132 (48.7) | 1.1 (0.7-1.6) | .77 |
| CC | 28 (13.9) | 29 (10.7) | 1.4 (0.7-2.7) | .29 |
| −899T>G | ||||
| TT | 114 (57.9) | 149 (55.0) | 1 (referent) | — |
| TG | 70 (35.5) | 103 (38.0) | 0.9 (0.6-1.3) | .62 |
| GG | 13 (6.6) | 19 (7.0) | 0.9 (0.4-2.0) | .85 |
| −791T>C | ||||
| TT | 70 (34.8) | 99 (36.5) | 1 (referent) | — |
| TC | 97 (48.3) | 133 (49.1) | 1.0 (0.7-1.6) | .92 |
| CC | 34 (16.9) | 39 (14.4) | 1.2 (0.7-2.2) | .48 |
| CDKN1B | ||||
| −1857C>T | ||||
| CC | 166 (80.6) | 209 (79.5) | 1 (referent) | — |
| CT | 39 (18.9) | 52 (19.8) | 0.9 (0.6-1.5) | .91 |
| TT | 1 (0.5) | 2 (0.7) | 0.6 (0.01-12.2) | .99 |
| −1608G>A | ||||
| GG | 184 (78.6) | 231 (84.9) | 1 (referent) | — |
| GA | 50 (21.4) | 37 (13.6) | 1.7 (1.0-2.8) | .03 |
| AA | 0 (0) | 4 (1.5) | — | — |
| −373G>T | ||||
| GG | 77 (35.0) | 89 (32.1) | 1 (referent) | — |
| GT | 107 (48.6) | 138 (49.8) | 0.9 (0.6-1.4) | .61 |
| TT | 36 (16.4) | 50 (18.1) | 0.8 (0.5-1.5) | .51 |
Percentages indicate number of individuals with a given genotype/total number of genotyped individuals.
OR indicates crude odds ratio; —, not applicable.