Allele frequencies of promoter SNPs in CDKN2A, CDKN2B, CDKN1A, and CDKN1B in childhood pre-B ALL patients and controls
| Genes, DNA variants, and alleles . | No. (%) . | OR (95% CI) . | P . | |
|---|---|---|---|---|
| ALL patients . | Controls . | |||
| CDKN2A | ||||
| −222T>A | ||||
| −222T | 420 (92.5) | 530 (96.4) | 1 (referent) | — |
| −222A | 34 (7.5) | 20 (3.6) | 2.2 (1.2-4.0) | .008* |
| CDKN2B | ||||
| −1270C>T | ||||
| −1270C | 418 (95.4) | 535 (96.9) | 1 (referent) | — |
| −1270T | 20 (4.6) | 17 (3.1) | 1.5 (0.7-3.1) | .24 |
| −593A>T, C | ||||
| −593A | 289 (66.6) | 326 (59.9) | 1 (referent) | — |
| −593T | 134 (30.9) | 206 (37.9) | 0.7 (0.6-1.0) | .02 |
| −593C | 11 (2.5) | 12 (2.2) | 1.0 (0.4-2.6) | .99 |
| −287G>C | ||||
| −287G | 250 (57.3) | 309 (56.4) | 1 (referent) | — |
| −287C | 186 (42.7) | 239 (43.6) | 1.0 (0.7-1.3) | .80 |
| CDKN1A | ||||
| −1284T>C | ||||
| −1284T | 249 (61.9) | 352 (64.9) | 1 (referent) | — |
| −1284C | 153 (38.1) | 190 (35.1) | 1.1 (0.9-1.5) | .37 |
| −899T>G | ||||
| −899T | 298 (75.6) | 401 (74.0) | 1 (referent) | — |
| −899G | 96 (24.4) | 141 (26.0) | 0.9 (0.7-1.3) | .59 |
| −791T>C | ||||
| −791T | 237 (59.0) | 331 (61.1) | 1 (referent) | — |
| −791C | 165 (41.0) | 211 (38.9) | 1.1 (0.9-1.5) | .46 |
| CDKN1B | ||||
| −1857C>T | ||||
| −1857C | 371 (90.1) | 470 (89.4) | 1 (referent) | — |
| −1857T | 41 (10.0) | 56 (10.7) | 0.9 (0.6-1.5) | .75 |
| −1608G>A | ||||
| −1608G | 418 (89.3) | 483 (91.8) | 1 (referent) | — |
| −1608A | 50 (10.7) | 43 (8.2) | 1.3 (0.9-2.1) | .19 |
| −373G>T | ||||
| −373G | 261 (59.3) | 316 (57.0) | 1 (referent) | — |
| −373T | 179 (40.7) | 238 (43.0) | 0.9 (0.7-1.2) | .48 |
| Genes, DNA variants, and alleles . | No. (%) . | OR (95% CI) . | P . | |
|---|---|---|---|---|
| ALL patients . | Controls . | |||
| CDKN2A | ||||
| −222T>A | ||||
| −222T | 420 (92.5) | 530 (96.4) | 1 (referent) | — |
| −222A | 34 (7.5) | 20 (3.6) | 2.2 (1.2-4.0) | .008* |
| CDKN2B | ||||
| −1270C>T | ||||
| −1270C | 418 (95.4) | 535 (96.9) | 1 (referent) | — |
| −1270T | 20 (4.6) | 17 (3.1) | 1.5 (0.7-3.1) | .24 |
| −593A>T, C | ||||
| −593A | 289 (66.6) | 326 (59.9) | 1 (referent) | — |
| −593T | 134 (30.9) | 206 (37.9) | 0.7 (0.6-1.0) | .02 |
| −593C | 11 (2.5) | 12 (2.2) | 1.0 (0.4-2.6) | .99 |
| −287G>C | ||||
| −287G | 250 (57.3) | 309 (56.4) | 1 (referent) | — |
| −287C | 186 (42.7) | 239 (43.6) | 1.0 (0.7-1.3) | .80 |
| CDKN1A | ||||
| −1284T>C | ||||
| −1284T | 249 (61.9) | 352 (64.9) | 1 (referent) | — |
| −1284C | 153 (38.1) | 190 (35.1) | 1.1 (0.9-1.5) | .37 |
| −899T>G | ||||
| −899T | 298 (75.6) | 401 (74.0) | 1 (referent) | — |
| −899G | 96 (24.4) | 141 (26.0) | 0.9 (0.7-1.3) | .59 |
| −791T>C | ||||
| −791T | 237 (59.0) | 331 (61.1) | 1 (referent) | — |
| −791C | 165 (41.0) | 211 (38.9) | 1.1 (0.9-1.5) | .46 |
| CDKN1B | ||||
| −1857C>T | ||||
| −1857C | 371 (90.1) | 470 (89.4) | 1 (referent) | — |
| −1857T | 41 (10.0) | 56 (10.7) | 0.9 (0.6-1.5) | .75 |
| −1608G>A | ||||
| −1608G | 418 (89.3) | 483 (91.8) | 1 (referent) | — |
| −1608A | 50 (10.7) | 43 (8.2) | 1.3 (0.9-2.1) | .19 |
| −373G>T | ||||
| −373G | 261 (59.3) | 316 (57.0) | 1 (referent) | — |
| −373T | 179 (40.7) | 238 (43.0) | 0.9 (0.7-1.2) | .48 |
Percentages indicate number of chromosomes with given allele/total number of chromosomes.
OR indicates crude odds ratio; —, not applicable.
Remained significant following multiple test correction with an FDR of 10%.