Histologic subtype of parental HL tumor, origin, and TACI, BCMA, BAFF-R, HSPG, BAFF, and APRIL expression profiles of HRS cell lines
| HRS cell line . | Subtype . | Origin* . | TACI . | BCMA . | APRIL . |
|---|---|---|---|---|---|
| HD-MyZ | NS | B | + | + | + |
| HD-LM2 | NS | T | − | − | −† |
| L428 | NS | B | + | +/−‡ | + |
| KM-H2 | MC | B | + | + | + |
| L1236 | MC | B | + | + | + |
| HRS cell line . | Subtype . | Origin* . | TACI . | BCMA . | APRIL . |
|---|---|---|---|---|---|
| HD-MyZ | NS | B | + | + | + |
| HD-LM2 | NS | T | − | − | −† |
| L428 | NS | B | + | +/−‡ | + |
| KM-H2 | MC | B | + | + | + |
| L1236 | MC | B | + | + | + |
All HRS cell lines were negative for the EBV protein latent-membrane protein-1 and for BAFF-R and were positive for HSPGs expressing the heparinitase-sensitive 3G10 epitope and BAFF.
NS indicates nodular sclerosis; MC, mixed cellularity (Drexler62 ; Kanzler et al63 ; and Wolf et al64 ).
*B- or T-cell derivation was established by detecting rearrangements of Ig and TCR loci, respectively (Drexler62 ; Kanzler et al63 ; and Wolf et al64 ).
†Although containing APRIL transcripts, HD-LM2 cells lacked APRIL protein.
‡Weak expression.