Table 4 Prognostic impact of CXCR4 and... | American Society of Hematology

Table 4

Prognostic impact of CXCR4 and other prognostic variables on overall survival and relapse-free survival

Variable	Univariate			Multivariate
Variable	HR	95% CI	P	HR	95% CI	P
Overall survival*
CXCR4 MFIR	2.699	1.327-5.489	.006	2.007	1.044-3.858	.037
LDH level	2.436	1.152-5.151	.02	—	—	—
Unfavorable cytogenetics	2.182	1.146-4.154	.018	2.478	1.129-5.441	.024
Relapse-free survival†
CXCR4 MFIR	3.853	1.298-11.442	.015	3.853	1.298-11.442	.015
WBC count	0.315	0.124-0.802	.015	—	—	—
Unfavorable cytogenetics	2.283	0.986-5.286	.054	—	—	—

Variable	Univariate			Multivariate
Variable	HR	95% CI	P	HR	95% CI	P
Overall survival*
CXCR4 MFIR	2.699	1.327-5.489	.006	2.007	1.044-3.858	.037
LDH level	2.436	1.152-5.151	.02	—	—	—
Unfavorable cytogenetics	2.182	1.146-4.154	.018	2.478	1.129-5.441	.024
Relapse-free survival†
CXCR4 MFIR	3.853	1.298-11.442	.015	3.853	1.298-11.442	.015
WBC count	0.315	0.124-0.802	.015	—	—	—
Unfavorable cytogenetics	2.283	0.986-5.286	.054	—	—	—

In this analysis, CXCR4 MFIR values were analyzed as a numeric variable without grouping into low, intermediate, or high expression (groups A to C).

HR indicates hazard ratio; CI, confidence interval; —, not applicable.

n = 90.

n = 60.