Influence of recombinant asparaginase treatment on coagulation parameters (mean ± SD)
| Parameter . | Baseline . | Day 15 . | Day 21 . | Day 27 . | Day 33 . | Day 39 . |
|---|---|---|---|---|---|---|
| PT (s) | 13.5 ± 2.1 | 12.1 ± 1.4 | 13.4 ± 2.4 | 14.3 ± 3.7 | 18.9 ± 23.4 | 11.0 ± 1.1 |
| PTT (s) | 27.2 ± 4.5 | 43.3 ± 44.0 | 61.5 ± 45.1 | 80.5 ± 57.2 | 50.3 ± 42.2 | 37.5 ± 19.1 |
| Fibrinogen (g/L) | 2.77 ± 1.06 | 0.99 ± 0.32 | 0.83 ± 0.53 | 0.74 ± 0.42 | 1.13 ± 1.05 | 2.37 ± 1.36 |
| AT III (U/mL) | 0.98 ± 0.15 | 0.94 ± 0.13 | 0.74 ± 0.14 | 0.65 ± 0.18 | 0.62 ± 0.21 | 0.89 ± 0.22 |
| D dimer (mg/L) | 0.82 ± 0.79 | 0.30 ± 0.39 | 0.17 ± 0.13 | 0.14 ± 0.08 | 0.23 ± 0.28 | 0.18 ± 0.14 |
| Parameter . | Baseline . | Day 15 . | Day 21 . | Day 27 . | Day 33 . | Day 39 . |
|---|---|---|---|---|---|---|
| PT (s) | 13.5 ± 2.1 | 12.1 ± 1.4 | 13.4 ± 2.4 | 14.3 ± 3.7 | 18.9 ± 23.4 | 11.0 ± 1.1 |
| PTT (s) | 27.2 ± 4.5 | 43.3 ± 44.0 | 61.5 ± 45.1 | 80.5 ± 57.2 | 50.3 ± 42.2 | 37.5 ± 19.1 |
| Fibrinogen (g/L) | 2.77 ± 1.06 | 0.99 ± 0.32 | 0.83 ± 0.53 | 0.74 ± 0.42 | 1.13 ± 1.05 | 2.37 ± 1.36 |
| AT III (U/mL) | 0.98 ± 0.15 | 0.94 ± 0.13 | 0.74 ± 0.14 | 0.65 ± 0.18 | 0.62 ± 0.21 | 0.89 ± 0.22 |
| D dimer (mg/L) | 0.82 ± 0.79 | 0.30 ± 0.39 | 0.17 ± 0.13 | 0.14 ± 0.08 | 0.23 ± 0.28 | 0.18 ± 0.14 |