Serum levels of glutamine and glutamic acid (median/range)
| Protocol day . | Glutamine (μmol/L) . | Glutamic acid (μmol/L) . | ||
|---|---|---|---|---|
| Recombinant asparaginase . | Asparaginase medac . | Recombinant asparaginase . | Asparaginase medac . | |
| 12 | 405(289-1050) | 418(285-767) | 36(11-114) | 39(22-155) |
| 15 | 371(226-834) | 379(286-983) | 43(19-114) | 51(24-138) |
| 21 | 469(13-921) | 419(254-536) | 50(1-71) | 56(36-112) |
| 27 | 443(204-1021) | 351(43-489) | 47(30-80) | 58(4-97) |
| 33 | 537(112-1180) | 384(304-683) | 50(25-96) | 67(31-173) |
| 39 | 493(277-642) | 427(220-632) | 63(49-106) | 70(39-98) |
| 64 | 469(351-1379) | 502(196-766) | 32(12-67) | 31(9-738) |
| Protocol day . | Glutamine (μmol/L) . | Glutamic acid (μmol/L) . | ||
|---|---|---|---|---|
| Recombinant asparaginase . | Asparaginase medac . | Recombinant asparaginase . | Asparaginase medac . | |
| 12 | 405(289-1050) | 418(285-767) | 36(11-114) | 39(22-155) |
| 15 | 371(226-834) | 379(286-983) | 43(19-114) | 51(24-138) |
| 21 | 469(13-921) | 419(254-536) | 50(1-71) | 56(36-112) |
| 27 | 443(204-1021) | 351(43-489) | 47(30-80) | 58(4-97) |
| 33 | 537(112-1180) | 384(304-683) | 50(25-96) | 67(31-173) |
| 39 | 493(277-642) | 427(220-632) | 63(49-106) | 70(39-98) |
| 64 | 469(351-1379) | 502(196-766) | 32(12-67) | 31(9-738) |
Serum levels were measured before asparaginase infusions 1 (day 12 = baseline), 2, 4, 6, and 8, as well as 6 days (day 39) and 1 month (day 64) after last asparaginase infusion.