Pharmacokinetic parameters of serum activities of asparaginase
| Parameter . | Recombinant asparaginase, N = 14 . | Asparaginase medac, N = 16 . | P . |
|---|---|---|---|
| AUC0-72h (U · h/L) | |||
| Median | 60 164.5 | 69 135.6 | .02 |
| Range | 38 626.8-80 764.3 | 49 243.8-83 850.1 | |
| Cmax (U/L) | |||
| Median | 3526.7 | 3699.8 | .21 |
| Range | 2231.3-4525.5 | 2898.2-4968.0 | |
| t1/2 λz (h) | |||
| Median | 17.3295 | 18.5499 | .19 |
| Range | 12.5392-22.9148 | 12.7322-27.3761 | |
| Cltot (L/h) | |||
| Median | 0.053 | 0.050 | .12 |
| Range | 0.043-0.178 | 0.027-0.117 | |
| Vdss (L) | |||
| Median | 0.948 | 0.966 | .24 |
| Range | 0.691-2.770 | 0.413-2.327 | |
| Parameter . | Recombinant asparaginase, N = 14 . | Asparaginase medac, N = 16 . | P . |
|---|---|---|---|
| AUC0-72h (U · h/L) | |||
| Median | 60 164.5 | 69 135.6 | .02 |
| Range | 38 626.8-80 764.3 | 49 243.8-83 850.1 | |
| Cmax (U/L) | |||
| Median | 3526.7 | 3699.8 | .21 |
| Range | 2231.3-4525.5 | 2898.2-4968.0 | |
| t1/2 λz (h) | |||
| Median | 17.3295 | 18.5499 | .19 |
| Range | 12.5392-22.9148 | 12.7322-27.3761 | |
| Cltot (L/h) | |||
| Median | 0.053 | 0.050 | .12 |
| Range | 0.043-0.178 | 0.027-0.117 | |
| Vdss (L) | |||
| Median | 0.948 | 0.966 | .24 |
| Range | 0.691-2.770 | 0.413-2.327 | |