Recent studies evaluating the risk of lymphoma in patients with celiac disease
| Study and year published . | Risk of being diagnosed with lymphoma . | Suggestion that GFD may be protective . | ||
|---|---|---|---|---|
| All NHL . | ETL . | Other NHL . | ||
| Catassi et al,144 2002 | OR = 3.1 | NR | Gut NHL: OR = 16.9; Any T-cell NHL: OR = 19.2 | NR |
| Askling et al,145 2002 | SIR = 5.9 | NR | NR | Yes |
| Green et al,149 2003 | SMR = 5.3-9.1 | NR | NR | No |
| Card et al,164 2004 | SIR = 5.8 | NR | Gut NHL: SIR = 40.5 | NR |
| Smedby et al,148 2005 | SIR = 6.6 | NR | Gut NHL: SIR = 24; Any T-cell NHL: SIR = 51; Non-GI NHL: SIR = 3.6 | NR |
| Mearin et al,163 2006* | OR = 2.6 | OR = 28 | Gut NHL: OR = 11.8 | NR |
| Viljamaa et al,162 2006 | SIR = 3.2 | NR | NR | Yes |
| Smedby et al,161 2006 | OR = 2.1 | NR | Gut NHL: OR = 12; Any T-cell NHL: OR = 17; DLBCL: OR = 2.8 | No |
| Study and year published . | Risk of being diagnosed with lymphoma . | Suggestion that GFD may be protective . | ||
|---|---|---|---|---|
| All NHL . | ETL . | Other NHL . | ||
| Catassi et al,144 2002 | OR = 3.1 | NR | Gut NHL: OR = 16.9; Any T-cell NHL: OR = 19.2 | NR |
| Askling et al,145 2002 | SIR = 5.9 | NR | NR | Yes |
| Green et al,149 2003 | SMR = 5.3-9.1 | NR | NR | No |
| Card et al,164 2004 | SIR = 5.8 | NR | Gut NHL: SIR = 40.5 | NR |
| Smedby et al,148 2005 | SIR = 6.6 | NR | Gut NHL: SIR = 24; Any T-cell NHL: SIR = 51; Non-GI NHL: SIR = 3.6 | NR |
| Mearin et al,163 2006* | OR = 2.6 | OR = 28 | Gut NHL: OR = 11.8 | NR |
| Viljamaa et al,162 2006 | SIR = 3.2 | NR | NR | Yes |
| Smedby et al,161 2006 | OR = 2.1 | NR | Gut NHL: OR = 12; Any T-cell NHL: OR = 17; DLBCL: OR = 2.8 | No |
GFD indicates gluten-free diet; NHL, non-Hodgkin lymphoma; ETL, enteropathy-type T-cell lymphoma; SIR, standardized incidence ratio; SMR, standardized morbidity ratio; NR, not reported; and DLBCL, diffuse large B-cell lymphoma.
There was a marked difference in the observed odds ratio for lymphoma between centers in this multicenter European study.