Table 1 Hematologic manifestations of CD... | American Society of Hematology

Table 1

Hematologic manifestations of CD

Problem	Frequency	Comments
Anemia: iron deficiency, folate deficiency, vitamin B₁₂ deficiency, and other nutritional deficiencies	Common	The anemia is most commonly secondary to iron deficiency but may be multifactorial in etiology. Low serum levels of folate and vitamin B₁₂ without anemia are frequently seen. Anemia due to other deficiencies appears to be rare.
Thrombocytopenia	Rare	May be associated with other autoimmune phenomena
Thrombocytosis	Common	May be secondary to iron deficiency or hyposplenism
Thromboembolism	Uncommon	Etiology is unknown but may be related to elevated levels of homocysteine or other procoagulants.
Leukopenia/neutropenia	Uncommon	Can be autoimmune or secondary to deficiencies of folate, vitamin B₁₂, or copper
Coagulopathy	Uncommon	Malabsorption of vitamin K
Hyposplenism	Common	Rarely associated with infections
IgA deficiency	Common	May be related to anaphylactic transfusion reactions
Lymphoma	Uncommon	The risk is highest for intestinal T-cell lymphomas

Problem	Frequency	Comments
Anemia: iron deficiency, folate deficiency, vitamin B₁₂ deficiency, and other nutritional deficiencies	Common	The anemia is most commonly secondary to iron deficiency but may be multifactorial in etiology. Low serum levels of folate and vitamin B₁₂ without anemia are frequently seen. Anemia due to other deficiencies appears to be rare.
Thrombocytopenia	Rare	May be associated with other autoimmune phenomena
Thrombocytosis	Common	May be secondary to iron deficiency or hyposplenism
Thromboembolism	Uncommon	Etiology is unknown but may be related to elevated levels of homocysteine or other procoagulants.
Leukopenia/neutropenia	Uncommon	Can be autoimmune or secondary to deficiencies of folate, vitamin B₁₂, or copper
Coagulopathy	Uncommon	Malabsorption of vitamin K
Hyposplenism	Common	Rarely associated with infections
IgA deficiency	Common	May be related to anaphylactic transfusion reactions
Lymphoma	Uncommon	The risk is highest for intestinal T-cell lymphomas