Baseline characteristics
| Baseline characteristic . | Value . |
|---|---|
| Median age, y (range) | 62.5 (44-88) |
| Median time from diagnosis to on-study, mo (range) | 8.8 (0.4-216) |
| No. of patients previously treated (%) | 13 (59) |
| Median no. of prior regimens (range) | 1 (0-3) |
| Prior hematopoietic stem cell transplantation, no. (%) | 6 (27) |
| Median NYHA class (range) | 1 (1-3) |
| ECOG performance status of 2 or more, no. (%) | 6 (27) |
| Median no. of organs involved (range) | 2 (0-3) |
| Organ involvement, no. of patients (%) | |
| Heart | 14 (64) |
| Kidney | 16 (73) |
| Liver | 5 (23) |
| Nerve | 1 (5) |
| Clonality, no. λ (%)/ no. κ (%) | 12 (55)/10 (45) |
| Median creatinine level, mg/dL (range) | 1.3 (0.7-2.6) |
| Median alkaline phosphatase level, IU/L (range) | 102.5 (57-1729) |
| Median bilirubin level, mg/dL (range) | 0.5 (0.3-2.8) |
| Median albumin level, g/dL (range) | 2.80 (1.20-3.70) |
| Median beta2 microglobulin level, mg/L (range) | 3.5 (1.4-8.4) |
| Median serum troponin level, μg/L (range) | 0.03 (0.1-0.55) |
| Median NT-proBNP level, ng/L (range) | 1 324.5 (109-42 844) |
| Troponin T/NT-proBNP stage,* no. of patients (%) | |
| Stage I | 4 (18) |
| Stage II | 13 (59) |
| Stage III | 5 (23) |
| Median serum M-protein level, g/dL (range) | 0.1 (0-1.7) |
| Median urine M-protein level, g/24 h (range) | 0.1 (0-0.889) |
| Median involved immunoglobulin free light chain level, mg/dL (range) | 19.6 (2.26-705) |
| Median no. of inv/uninvolved free light chains (range) | 12.1 (0.95-3711) |
| Median total urine protein level, g/24 h (range) | 4 328 (25-14 276) |
| Median interventricular septal thickness, mm (range) | 13 (9-24) |
| Median left ventricular ejection fraction, % (range) | 63.5 (22-72) |
| Baseline characteristic . | Value . |
|---|---|
| Median age, y (range) | 62.5 (44-88) |
| Median time from diagnosis to on-study, mo (range) | 8.8 (0.4-216) |
| No. of patients previously treated (%) | 13 (59) |
| Median no. of prior regimens (range) | 1 (0-3) |
| Prior hematopoietic stem cell transplantation, no. (%) | 6 (27) |
| Median NYHA class (range) | 1 (1-3) |
| ECOG performance status of 2 or more, no. (%) | 6 (27) |
| Median no. of organs involved (range) | 2 (0-3) |
| Organ involvement, no. of patients (%) | |
| Heart | 14 (64) |
| Kidney | 16 (73) |
| Liver | 5 (23) |
| Nerve | 1 (5) |
| Clonality, no. λ (%)/ no. κ (%) | 12 (55)/10 (45) |
| Median creatinine level, mg/dL (range) | 1.3 (0.7-2.6) |
| Median alkaline phosphatase level, IU/L (range) | 102.5 (57-1729) |
| Median bilirubin level, mg/dL (range) | 0.5 (0.3-2.8) |
| Median albumin level, g/dL (range) | 2.80 (1.20-3.70) |
| Median beta2 microglobulin level, mg/L (range) | 3.5 (1.4-8.4) |
| Median serum troponin level, μg/L (range) | 0.03 (0.1-0.55) |
| Median NT-proBNP level, ng/L (range) | 1 324.5 (109-42 844) |
| Troponin T/NT-proBNP stage,* no. of patients (%) | |
| Stage I | 4 (18) |
| Stage II | 13 (59) |
| Stage III | 5 (23) |
| Median serum M-protein level, g/dL (range) | 0.1 (0-1.7) |
| Median urine M-protein level, g/24 h (range) | 0.1 (0-0.889) |
| Median involved immunoglobulin free light chain level, mg/dL (range) | 19.6 (2.26-705) |
| Median no. of inv/uninvolved free light chains (range) | 12.1 (0.95-3711) |
| Median total urine protein level, g/24 h (range) | 4 328 (25-14 276) |
| Median interventricular septal thickness, mm (range) | 13 (9-24) |
| Median left ventricular ejection fraction, % (range) | 63.5 (22-72) |
N = 22.
To convert creatinine level from milligrams per deciliter to micromoles per liter, multiply milligrams per deciliter by 88.4. To convert bilirubin level from milligrams per deciliter to micromoles per liter, multiply milligrams per deciliter by 17.1. To convert albumin level from grams per deciliter to grams per liter, multiply grams per deciliter by 10. To convert beta2 microglobulin from milligrams per liter to nonomoles per liter, multiply milligrams per liter by 85.
Troponin T/NT-proBNP staging uses the cutoffs of < 0.035 μg/L for troponin T and < 334 ng/L for NT-proBNP. Stage I indicates that both levels are below threshold; stage II, one level is above threshold; and stage III, both levels are above threshold.