Effect of palifermin and methotrexate on oral mucositis severity
. | Maximum grade of oral mucositis, no. (%) . | . | . | . | . | . | ||||
|---|---|---|---|---|---|---|---|---|---|---|
. | 0 . | 1 . | 2 . | 3 . | 4 . | P* . | ||||
| Palifermin | .42 | |||||||||
| With methotrexate on day 11 | 4 (8) | 4 (8) | 8 (16) | 33 (67) | 0 (0) | |||||
| Without methotrexate on day 11 | 1 (6) | 3 (19) | 2 (13) | 10 (63) | 0 (0) | |||||
| Placebo | ||||||||||
| With methotrexate on day 11 | 0 (0) | 0 (0) | 7 (27) | 18 (69) | 1 (4) | |||||
| Without methotrexate on day 11 | 0 (0) | 0 (0) | 0 (0) | 4 (80) | 1 (20) | |||||
. | Maximum grade of oral mucositis, no. (%) . | . | . | . | . | . | ||||
|---|---|---|---|---|---|---|---|---|---|---|
. | 0 . | 1 . | 2 . | 3 . | 4 . | P* . | ||||
| Palifermin | .42 | |||||||||
| With methotrexate on day 11 | 4 (8) | 4 (8) | 8 (16) | 33 (67) | 0 (0) | |||||
| Without methotrexate on day 11 | 1 (6) | 3 (19) | 2 (13) | 10 (63) | 0 (0) | |||||
| Placebo | ||||||||||
| With methotrexate on day 11 | 0 (0) | 0 (0) | 7 (27) | 18 (69) | 1 (4) | |||||
| Without methotrexate on day 11 | 0 (0) | 0 (0) | 0 (0) | 4 (80) | 1 (20) | |||||
P value is comparison of grades 0 to 2 versus 3 to 4 in groups with or without day 11 methotrexate by palifermin versus placebo.