Discontinuations for patients receiving placebo or palifermin
. | . | Palifermin . | . | . | . | . | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| . | . | Cohort 1 . | . | Cohort 2 . | Cohort 3 . | . | ||||
. | Placebo . | 40 μg/kg or 240 μg/kg total dose . | 60 μg/kg or 360 μg/kg total dose . | 60 μg/kg or 540 μg/kg total dose . | 60 μg/kg or 720 μg/kg total dose . | All . | ||||
| Patients randomly assigned, no. | 31 | 8 | 10 | 14 | 37 | 69 | ||||
| Patients discontinued and replaced, no. (%) | 1 (3) | 1 (13) | 0 | 2 (14) | 14 (38) | 17 (25) | ||||
| Patients with DLT who discontinued and were not replaced, no. (%) | 1 (3) | 0 | 0 | 2 (14) | 1 (3) | 3 (4) | ||||
| Deaths of patients who received a transplant, no. (%) | 5 (16) | 2 (25)* | 1 (10) | 3 (21) | 6 (17)* | 12 (18) | ||||
. | . | Palifermin . | . | . | . | . | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| . | . | Cohort 1 . | . | Cohort 2 . | Cohort 3 . | . | ||||
. | Placebo . | 40 μg/kg or 240 μg/kg total dose . | 60 μg/kg or 360 μg/kg total dose . | 60 μg/kg or 540 μg/kg total dose . | 60 μg/kg or 720 μg/kg total dose . | All . | ||||
| Patients randomly assigned, no. | 31 | 8 | 10 | 14 | 37 | 69 | ||||
| Patients discontinued and replaced, no. (%) | 1 (3) | 1 (13) | 0 | 2 (14) | 14 (38) | 17 (25) | ||||
| Patients with DLT who discontinued and were not replaced, no. (%) | 1 (3) | 0 | 0 | 2 (14) | 1 (3) | 3 (4) | ||||
| Deaths of patients who received a transplant, no. (%) | 5 (16) | 2 (25)* | 1 (10) | 3 (21) | 6 (17)* | 12 (18) | ||||
One patient was replaced.