Toxicity observed with flavopiridol
| . | No. patients with toxicities (%) . | |
|---|---|---|
| Grade 3 . | Grade 4 . | |
| Hematologic | ||
| ANC | 0 (0) | 30 (77) |
| Hgb | 6 (15) | 1 (3) |
| Platelets | 8 (21) | 7 (18) |
| Hemorrhage | 3 (8) | 0 (0) |
| Thrombosis | 1 (3) | 0 (0) |
| Cardiac | ||
| Hypotension | 1 (3) | 3 (8) |
| Tachycardia or SVT | 2 (6) | 0 (0) |
| Atrioventricular heart block | 1 (3) | 0 (0) |
| Chest pain | 1 (3) | 0 (0) |
| Respiratory | ||
| Dyspnea | 3 (8) | 0 (0) |
| Hypoxia | 4 (10) | 2 (5) |
| Apnea | 1 (3) | 0 (0) |
| Respiratory failure | 0 (0) | 1 (3) |
| GI/Hepatic | ||
| Diarrhea | 16 (41) | 0 (0) |
| Abdominal pain/cramping | 2 (5) | 0 (0) |
| AST or ALT | 11 (28) | 2 (5) |
| Bilirubin | 1 (3) | 0 (0) |
| Renal* | ||
| Renal failure | 2 (5) | 1 (3) |
| CNS | ||
| Seizure | 0 (0) | 1 (3) |
| CNS cerebrovascular inschemia | 0 (0) | 1 (3) |
| Neuropathic pain | 1 (3) | 0 (0) |
| Possible infection | ||
| Fever without neutropenia | 3 (8) | 0 (0) |
| Febrile neutropenia | 4 (10) | 0 (0) |
| Infection with neutropenia | 6 (15) | 1 (3) |
| Infection without neutropenia | 1 (3) | 0 (0) |
| Other | ||
| Edema | 1 (3) | 1 (3) |
| Fatigue | 7 (18) | 1 (3) |
| Anorexia | 3 (8) | 0 (0) |
| Biochemical tumor lysis | 23 (55) | 0 (0) |
| . | No. patients with toxicities (%) . | |
|---|---|---|
| Grade 3 . | Grade 4 . | |
| Hematologic | ||
| ANC | 0 (0) | 30 (77) |
| Hgb | 6 (15) | 1 (3) |
| Platelets | 8 (21) | 7 (18) |
| Hemorrhage | 3 (8) | 0 (0) |
| Thrombosis | 1 (3) | 0 (0) |
| Cardiac | ||
| Hypotension | 1 (3) | 3 (8) |
| Tachycardia or SVT | 2 (6) | 0 (0) |
| Atrioventricular heart block | 1 (3) | 0 (0) |
| Chest pain | 1 (3) | 0 (0) |
| Respiratory | ||
| Dyspnea | 3 (8) | 0 (0) |
| Hypoxia | 4 (10) | 2 (5) |
| Apnea | 1 (3) | 0 (0) |
| Respiratory failure | 0 (0) | 1 (3) |
| GI/Hepatic | ||
| Diarrhea | 16 (41) | 0 (0) |
| Abdominal pain/cramping | 2 (5) | 0 (0) |
| AST or ALT | 11 (28) | 2 (5) |
| Bilirubin | 1 (3) | 0 (0) |
| Renal* | ||
| Renal failure | 2 (5) | 1 (3) |
| CNS | ||
| Seizure | 0 (0) | 1 (3) |
| CNS cerebrovascular inschemia | 0 (0) | 1 (3) |
| Neuropathic pain | 1 (3) | 0 (0) |
| Possible infection | ||
| Fever without neutropenia | 3 (8) | 0 (0) |
| Febrile neutropenia | 4 (10) | 0 (0) |
| Infection with neutropenia | 6 (15) | 1 (3) |
| Infection without neutropenia | 1 (3) | 0 (0) |
| Other | ||
| Edema | 1 (3) | 1 (3) |
| Fatigue | 7 (18) | 1 (3) |
| Anorexia | 3 (8) | 0 (0) |
| Biochemical tumor lysis | 23 (55) | 0 (0) |
ANC indicates absolute neutrophil count; Hgb, hemoglobin; SVT, supraventricular tachycardia; GI, gastrointestinal; AST, aspartate aminotransferase; ALT, alanine aminotransferase; and CNS, central nervous system.
Excludes transient electrolyte abnormalities.