Correlation of CD38-expression profile of T cells with Zap-70, Ig VH mutational status, and genomic aberrations in male patients
Parameter . | No CD38 risk, no. patients* . | At least 50% CD38+ T cells, no patients . | P . |
|---|---|---|---|
| Zap-70 | .05 | ||
| Less than 20% positive B-CLL cells | 26 | 15 | |
| At least 20% positive B-CLL cells | 12 | 1 | |
| Homology to Ig VH germ line | .63 | ||
| Less than 98% homology | 21 | 13 | |
| At least 98% homology | 5 | 2 | |
| Genomic aberrations | .59 | ||
| Absent or 13q | 26 | 12 | |
| del11q, del17p, 12+ | 4 | 1 |
Parameter . | No CD38 risk, no. patients* . | At least 50% CD38+ T cells, no patients . | P . |
|---|---|---|---|
| Zap-70 | .05 | ||
| Less than 20% positive B-CLL cells | 26 | 15 | |
| At least 20% positive B-CLL cells | 12 | 1 | |
| Homology to Ig VH germ line | .63 | ||
| Less than 98% homology | 21 | 13 | |
| At least 98% homology | 5 | 2 | |
| Genomic aberrations | .59 | ||
| Absent or 13q | 26 | 12 | |
| del11q, del17p, 12+ | 4 | 1 |
The definition of “no CD38 risk” refers to patients with less than 50% CD38+ T cells and less than 30% CD38+ B-CLL cells.