Table 3.

Results of cleaved caspase-3 assay

Humanized mAbs, % relative to no mAb control
Murine mAbs, % relative to no mAb control
hL243γ4P
hA20
hMN-14
mL243
mMN-14
No cross-linking      
   Ramos   26.9   3.2   0.8   15.8   3.9  
   Namalwa   18.4   –0.1   0.2   9.4   0.5  
   FSCCL   46.4   0.7   0.3   26.2   –0.7  
   Daudi   48.1   7.9   0.9   45.8   1.0  
   RL   22.5   1.5   –0.1   18.2   –0.3  
   SU-DHL-6   52.2   30.9   2.3   46.5   0.2  
   Raji   22.5   1.5   –0.1   18.2   –0.3  
With second antibody      
   Ramos   71.7   67.8   7.3   40.3   3.0  
   Namalwa   72.2   20.4   7.9   25.2   –0.3  
   FSCCL   86.7   20.0   8.4   55.0   1.5  
   Daudi   68.9   72.0   2.9   51.2   0.0  
   RL   37.3   24.2   4.0   4.0   0.7  
   SU-DHL-6   72.1   75.8   5.5   51.4   –0.9  
   Raji
 		 59.8
 		 37.4
 		 2.8
 		 20.4
 		 –0.3
 
Humanized mAbs, % relative to no mAb control
Murine mAbs, % relative to no mAb control
hL243γ4P
hA20
hMN-14
mL243
mMN-14
No cross-linking      
   Ramos   26.9   3.2   0.8   15.8   3.9  
   Namalwa   18.4   –0.1   0.2   9.4   0.5  
   FSCCL   46.4   0.7   0.3   26.2   –0.7  
   Daudi   48.1   7.9   0.9   45.8   1.0  
   RL   22.5   1.5   –0.1   18.2   –0.3  
   SU-DHL-6   52.2   30.9   2.3   46.5   0.2  
   Raji   22.5   1.5   –0.1   18.2   –0.3  
With second antibody      
   Ramos   71.7   67.8   7.3   40.3   3.0  
   Namalwa   72.2   20.4   7.9   25.2   –0.3  
   FSCCL   86.7   20.0   8.4   55.0   1.5  
   Daudi   68.9   72.0   2.9   51.2   0.0  
   RL   37.3   24.2   4.0   4.0   0.7  
   SU-DHL-6   72.1   75.8   5.5   51.4   –0.9  
   Raji
 		 59.8
 		 37.4
 		 2.8
 		 20.4
 		 –0.3
 
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