Summary of hematopathologic characteristics of oncogenic NRAS mice
Experiment . | No. of animals . | Latency, d* . | WBCs, × 103/μL† . | Hematocrit, %‡ . | Spleen weight, g . | Liver weight, g . |
|---|---|---|---|---|---|---|
| 1 | ||||||
| HT | ||||||
| CMML | 3 | 36 | 75-103 | 25.3 ± 4.6 | 0.88 ± 0.1 | 1.59 ± 0.29 |
| AML | 5 | 41 | 14-40 | 24 ± 5.3 | 0.49 ± 0.0 | 1.2 ± 0.007 |
| LT | ||||||
| CMML | 6 | 62 | 77-207 | 31 ± 9.6 | 1.04 ± 0.6 | 1.65 ± 0.38 |
| AML | 6 | 57 | 16-48 | 27.5 ± 11.6 | 0.59 ± 0.08 | 1.47 ± 0.15 |
| 2 | ||||||
| HT | ||||||
| AML | 5 | 28 | 22-35 | 21.6 ± 13.3 | 0.91 ± 0.3 | 1.72 ± 0.54 |
| LT | ||||||
| CMML | 4 | 54 | 79-120 | 32 ± 5.4 | 0.7 ± 0.0 | 1.44 ± 0.23 |
| AML | 4 | 45 | 13-37 | 26.3 ± 14.3 | 0.73 ± 0.08 | 1.34 ± 0.06 |
| 3 | ||||||
| HT | ||||||
| AML | 6 | 30 | 12-55 | 21.5 ± 11.2 | 0.71 ± 0.14 | 1.53 ± 0.37 |
| LT | ||||||
| CMML | 2 | 75 | 64-141 | 31.5 ± 0.7 | 1.02 ± 0.01 | 2.5 ± 1.54 |
| AML | 4 | 87 | 16-43 | 36.3 ± 16.2 | 0.72 ± 0.5 | 0.99 ± 0.45 |
Experiment . | No. of animals . | Latency, d* . | WBCs, × 103/μL† . | Hematocrit, %‡ . | Spleen weight, g . | Liver weight, g . |
|---|---|---|---|---|---|---|
| 1 | ||||||
| HT | ||||||
| CMML | 3 | 36 | 75-103 | 25.3 ± 4.6 | 0.88 ± 0.1 | 1.59 ± 0.29 |
| AML | 5 | 41 | 14-40 | 24 ± 5.3 | 0.49 ± 0.0 | 1.2 ± 0.007 |
| LT | ||||||
| CMML | 6 | 62 | 77-207 | 31 ± 9.6 | 1.04 ± 0.6 | 1.65 ± 0.38 |
| AML | 6 | 57 | 16-48 | 27.5 ± 11.6 | 0.59 ± 0.08 | 1.47 ± 0.15 |
| 2 | ||||||
| HT | ||||||
| AML | 5 | 28 | 22-35 | 21.6 ± 13.3 | 0.91 ± 0.3 | 1.72 ± 0.54 |
| LT | ||||||
| CMML | 4 | 54 | 79-120 | 32 ± 5.4 | 0.7 ± 0.0 | 1.44 ± 0.23 |
| AML | 4 | 45 | 13-37 | 26.3 ± 14.3 | 0.73 ± 0.08 | 1.34 ± 0.06 |
| 3 | ||||||
| HT | ||||||
| AML | 6 | 30 | 12-55 | 21.5 ± 11.2 | 0.71 ± 0.14 | 1.53 ± 0.37 |
| LT | ||||||
| CMML | 2 | 75 | 64-141 | 31.5 ± 0.7 | 1.02 ± 0.01 | 2.5 ± 1.54 |
| AML | 4 | 87 | 16-43 | 36.3 ± 16.2 | 0.72 ± 0.5 | 0.99 ± 0.45 |
Hematocrit, spleen weight, and liver weight are average ± SD.
HT indicates high-titer retroviruses (∼ 7 × 106-8 × 106 TU/mL); LT, low-titer retroviruses (∼ 6 × 105-7 × 105TU/mL).
Latency is the median latency within the particular group.
WBC count is given as the range of WBCs for the diseased mice within a particular disease group; values also reflect the SI unit of measure, × 109/L.
Multiply values by 0.01 to obtain SI unit of measure (proportion of 1.0).