Summary of MDS-like/AML in SALL4B transgenic mice
Mouse ID . | Sex . | Founder . | Age, mo . | Phenotype . | Outcome and organs involved by AML* . |
|---|---|---|---|---|---|
| 464 | M | 464 | 19 | MDS-like | Died of MDS |
| 4 | M | 464 | 22 | MDS-like | Alive |
| 504 | M | 504 | 19 | MDS-like | Killed due to MDS |
| 86 | F | 504 | 18 | AML | Killed; AML in BM, PB, liver, spleen, LNs |
| 87 | F | 504 | 8 | AML | Killed; AML in BM, PB, liver, spleen, LNs |
| 506 | M | 506 | 19 | MDS-like | Killed due to MDS |
| 1336 | F | 506 | 14 | AML | Killed; AML in BM, liver, spleen, LNs |
| 2548 | F | 506 | 14 | AML | Killed; AML in BM, liver, spleen |
| 507 | F | 507 | 24 | AML | Died; AML in BM, PB, liver, spleen, LNs |
| 23 | M | 507 | 22 | MDS-like | Killed due to MDS |
| 25 | M | 507 | 8 | AML | Killed; AML in BM, PB, liver, spleen, LNs |
| 26 | M | 507 | 14 | MDS | Killed due to MDS |
| 27 | M | 507 | 22 | MDS-like | Alive |
| 3058 | F | 507 | 12 | AML | Died; AML in BM, PB, liver, spleen and LNs |
| 509 | F | 509 | 18 | AML | Killed; AML in BM, PB, liver, spleen, LNs, lung |
| 510 | F | 510 | 24 | MDS-like | Killed due to MDS |
Mouse ID . | Sex . | Founder . | Age, mo . | Phenotype . | Outcome and organs involved by AML* . |
|---|---|---|---|---|---|
| 464 | M | 464 | 19 | MDS-like | Died of MDS |
| 4 | M | 464 | 22 | MDS-like | Alive |
| 504 | M | 504 | 19 | MDS-like | Killed due to MDS |
| 86 | F | 504 | 18 | AML | Killed; AML in BM, PB, liver, spleen, LNs |
| 87 | F | 504 | 8 | AML | Killed; AML in BM, PB, liver, spleen, LNs |
| 506 | M | 506 | 19 | MDS-like | Killed due to MDS |
| 1336 | F | 506 | 14 | AML | Killed; AML in BM, liver, spleen, LNs |
| 2548 | F | 506 | 14 | AML | Killed; AML in BM, liver, spleen |
| 507 | F | 507 | 24 | AML | Died; AML in BM, PB, liver, spleen, LNs |
| 23 | M | 507 | 22 | MDS-like | Killed due to MDS |
| 25 | M | 507 | 8 | AML | Killed; AML in BM, PB, liver, spleen, LNs |
| 26 | M | 507 | 14 | MDS | Killed due to MDS |
| 27 | M | 507 | 22 | MDS-like | Alive |
| 3058 | F | 507 | 12 | AML | Died; AML in BM, PB, liver, spleen and LNs |
| 509 | F | 509 | 18 | AML | Killed; AML in BM, PB, liver, spleen, LNs, lung |
| 510 | F | 510 | 24 | MDS-like | Killed due to MDS |
Mice were killed when noticed to be ill. AML is defined to have more than 20% c-kit-positive immature cells in the bone marrow or peripheral blood, with leukemia cells involving multiple organs