Expression of histamine receptor (HR) mRNA in CML cells
. | . | Expression of mRNA . | . | . | ||
|---|---|---|---|---|---|---|
| Gene product . | Product size, bp . | Primary CML cells . | CD34+ CML cells . | Normal BMMCs . | ||
| HR-1 | 150 | +/– | + | +/– | ||
| HR-2 | 128 | + | + | + | ||
| HR-3 | 140 | – | – | – | ||
| HR-4 | 200 | + | + | + | ||
. | . | Expression of mRNA . | . | . | ||
|---|---|---|---|---|---|---|
| Gene product . | Product size, bp . | Primary CML cells . | CD34+ CML cells . | Normal BMMCs . | ||
| HR-1 | 150 | +/– | + | +/– | ||
| HR-2 | 128 | + | + | + | ||
| HR-3 | 140 | – | – | – | ||
| HR-4 | 200 | + | + | + | ||
Expression of transcripts specific for histamine receptors (HRs) type 1-4 in leukemic cells was analyzed by RT-PCR using primers specific for histamine receptors.
BMMC indicates bone marrow mononuclear cells; +/–, not detectable in all patients examined