Aberrations as detected by FISH are correlated to the IgVH status and CD38 expression
. | IgVH . | . | . | CD38* . | . | . | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| . | No. Patients . | . | . | No.Patients . | . | . | ||||
| FISH . | M . | UM . | P . | Negative . | Positive . | P . | ||||
| Normal | 10 | 15 | .409 | 17 | 5 | .414 | ||||
| del(6q) | 4 | 2 | .326 | 3 | 1 | .830 | ||||
| del(11q) | 2 | 14 | .003 | 8 | 11 | .003 | ||||
| del(13q) sole | 26 | 15 | .008 | 34 | 6 | .009 | ||||
| del(17p) | 2 | 4 | .483 | 4 | 1 | .623 | ||||
| +12 | 7 | 7 | .823 | 7 | 7 | .076 | ||||
. | IgVH . | . | . | CD38* . | . | . | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| . | No. Patients . | . | . | No.Patients . | . | . | ||||
| FISH . | M . | UM . | P . | Negative . | Positive . | P . | ||||
| Normal | 10 | 15 | .409 | 17 | 5 | .414 | ||||
| del(6q) | 4 | 2 | .326 | 3 | 1 | .830 | ||||
| del(11q) | 2 | 14 | .003 | 8 | 11 | .003 | ||||
| del(13q) sole | 26 | 15 | .008 | 34 | 6 | .009 | ||||
| del(17p) | 2 | 4 | .483 | 4 | 1 | .623 | ||||
| +12 | 7 | 7 | .823 | 7 | 7 | .076 | ||||
For IgVH M, n = 51; for UM, n = 58. For CD38-negative, n = 73; for CD38-positive, n = 31.
The cut-off for the separation of CD38-positive and -negative samples was 30% by flow cytometry.