CBC tests in E18.5 and P7 Sox6–/– and control mice
. | E18.5 . | . | . | P7 . | . | |||
|---|---|---|---|---|---|---|---|---|
. | Sox6+/+ . | Sox6+/- . | Sox6-/- . | Sox6+/- . | Sox6-/- . | |||
| No. | 6 | 12 | 11 | 4 | 4 | |||
| RBC count, 106/μL | 3.4 ± 0.1 | 3.3 ± 0.2 | 2.5 ± 0.5 (73%) | 4.7 ± 0.7 | 5.2 ± 1.3 | |||
| HCT, % | 37.9 ± 3.9 | 37.5 ± 5.9 | 27.1 ± 6.0 (72%) | 28.3 ± 4.3 | 31.0 ± 7.7 | |||
| HGB level, g/dL | 12.4 ± 2.9 | 10.2 ± 3.3 | 6.1 ± 0.9 (49%) | 7.2 ± 1.5 | 8.1 ± 2.4 | |||
| MCHC, g/dL | 35.9 ± 2.1 | 33.4 ± 2.0 | 22.6 ± 4.9 (66%) | 25.5 ± 1.6 | 25.8 ± 1.4 | |||
| RDW, % | 19.0 ± 1.7 | 20.0 ± 1.3 | 32.7 ± 3.1 (165%) | 16.5 ± 0.7 | 26.5 ± 1.8 (160%) | |||
| Reticulocytes, % | 27.0 ± 6.0 | 26.0 ± 11.0 | >40 (154%) | 17.3 ± 1.5 | 10.4 ± 2.3 (61%) | |||
. | E18.5 . | . | . | P7 . | . | |||
|---|---|---|---|---|---|---|---|---|
. | Sox6+/+ . | Sox6+/- . | Sox6-/- . | Sox6+/- . | Sox6-/- . | |||
| No. | 6 | 12 | 11 | 4 | 4 | |||
| RBC count, 106/μL | 3.4 ± 0.1 | 3.3 ± 0.2 | 2.5 ± 0.5 (73%) | 4.7 ± 0.7 | 5.2 ± 1.3 | |||
| HCT, % | 37.9 ± 3.9 | 37.5 ± 5.9 | 27.1 ± 6.0 (72%) | 28.3 ± 4.3 | 31.0 ± 7.7 | |||
| HGB level, g/dL | 12.4 ± 2.9 | 10.2 ± 3.3 | 6.1 ± 0.9 (49%) | 7.2 ± 1.5 | 8.1 ± 2.4 | |||
| MCHC, g/dL | 35.9 ± 2.1 | 33.4 ± 2.0 | 22.6 ± 4.9 (66%) | 25.5 ± 1.6 | 25.8 ± 1.4 | |||
| RDW, % | 19.0 ± 1.7 | 20.0 ± 1.3 | 32.7 ± 3.1 (165%) | 16.5 ± 0.7 | 26.5 ± 1.8 (160%) | |||
| Reticulocytes, % | 27.0 ± 6.0 | 26.0 ± 11.0 | >40 (154%) | 17.3 ± 1.5 | 10.4 ± 2.3 (61%) | |||
Percentages of wild-type values are shown in parentheses. Sox6-/- fetuses have greater than 40% reticulocytes, the ADVIA analyzer upper detection limit.
HCT indicates hematocrit; HGB, hemoglobin; and MCHC, mean cell hemoglobin concentration.