Representative laboratory values for patients 1 and 2 when well and not receiving G-CSF
. | Patient 1 . | Patient 2 . | Normal range . |
|---|---|---|---|
| Hemoglobin level, g/L | 110.0 | 104.0 | 105-135 |
| Mean WBC count, × 109/L | 1.69 (0.9-3.29) | 4.78 (2.7-5.6) | 5.0-15.0 |
| Platelet count, × 109/L, range | 153-218 | 172-353 | 150-450 |
| MPV, fL, range | 11.3-13.7 | NA* | 7.8-11.0 |
| Mean neutrophil count, × 109/L | 0.30 (0.17-0.47) | 0.19 (0.051-0.260) | 1.5-8.5 |
| Mean monocyte count, × 109/L | 0.11 (0.05-0.22) | NA | 0.3-1.5 |
| Mean lymphocyte count, × 109/L | 1.19 (0.48-2.59) | 3.96 (0.84-5.83) | 2.0-9.5 |
| Mean CD3+CD4+ count, × 109/L | 0.40 (0.23-0.53) | 1.1 | 0.56-2.7 (P1); 2.3-2.9 (P2)† |
| Mean CD3+CD8+ count, × 109/L | 0.43 (0.24-0.45) | 0.87 | 0.33-1.4 (P1); 0.35-2.5 (P2)† |
| CD16+CD56+, × 109/L, range | 0.01-0.03 | 0.02 | 0.1-1.0 |
| PHA stimulation, SI | 148 | 178 | > 40 |
| CD3 stimulation, SI | 1.5, 2.1§ | 3.7 | > 20 |
| Oxidative burst, PMA‡ | 81 | 94 | > 80 |
| Oxidative burst, E coli‡ | 36 | 70 | > 80 |
| Oxidative burst, fMLP‡ | 2 | 6 | > 20 |
| Phagocytosis | Low | Low | — |
. | Patient 1 . | Patient 2 . | Normal range . |
|---|---|---|---|
| Hemoglobin level, g/L | 110.0 | 104.0 | 105-135 |
| Mean WBC count, × 109/L | 1.69 (0.9-3.29) | 4.78 (2.7-5.6) | 5.0-15.0 |
| Platelet count, × 109/L, range | 153-218 | 172-353 | 150-450 |
| MPV, fL, range | 11.3-13.7 | NA* | 7.8-11.0 |
| Mean neutrophil count, × 109/L | 0.30 (0.17-0.47) | 0.19 (0.051-0.260) | 1.5-8.5 |
| Mean monocyte count, × 109/L | 0.11 (0.05-0.22) | NA | 0.3-1.5 |
| Mean lymphocyte count, × 109/L | 1.19 (0.48-2.59) | 3.96 (0.84-5.83) | 2.0-9.5 |
| Mean CD3+CD4+ count, × 109/L | 0.40 (0.23-0.53) | 1.1 | 0.56-2.7 (P1); 2.3-2.9 (P2)† |
| Mean CD3+CD8+ count, × 109/L | 0.43 (0.24-0.45) | 0.87 | 0.33-1.4 (P1); 0.35-2.5 (P2)† |
| CD16+CD56+, × 109/L, range | 0.01-0.03 | 0.02 | 0.1-1.0 |
| PHA stimulation, SI | 148 | 178 | > 40 |
| CD3 stimulation, SI | 1.5, 2.1§ | 3.7 | > 20 |
| Oxidative burst, PMA‡ | 81 | 94 | > 80 |
| Oxidative burst, E coli‡ | 36 | 70 | > 80 |
| Oxidative burst, fMLP‡ | 2 | 6 | > 20 |
| Phagocytosis | Low | Low | — |
Means and ranges in the first two columns (ranges in parentheses except where indicated) refer to 5 separate samples taken at different time points.
WBC indicates white blood cell; NA, not available; SI, stimulation index; and —, not applicable.
Large platelets seen on blood film.
Normal ranges differ according to age.
Percentage of cells reaching a threshold level of dihydrorhodamine 123 (DHR123) oxidation.
Two independent measurements.