Immunologic features of patient and her mother at last revision (March 2005)
. | Patient . | Mother . | Reference value . |
|---|---|---|---|
| Total lymphocytes, × 109/L | 2.073 | 1.542 | 1-4 |
| T lymphocytes, % | |||
| CD3+ | 91 | 80 | 61-82 |
| CD3+CD4+ | 25 | 50 | 36-56 |
| CD3+CD8+ | 39 | 24 | 13-31 |
| CD4/CD8 ratio | 0.64 | 2.18 | 1-2.5 |
| CD3+TcR-αβ+ | 88 | 74 | 55-75 |
| CD3+TcR-γδ+ | 1 | 5 | 0-7 |
| TcR-αβ+CD4-CD8- (DN) | 25* | 1 | 0-2 |
| CD3+CD95+ | 81 | 65 | 60¶ |
| T-activation markers, % | |||
| CD3+CD38+ | 22 | 6 | 0-8 |
| CD3+HLA-DR+ | 18† | 6 | 0-10 |
| CD19+ B lymphocytes, % | 5 | 9 | 5-18 |
| CD16+CD56+CD3-NK lymphocytes, % | 3 | 10 | 3-18 |
| Immunoglobulins, g/L | |||
| IgG | 17.6‡ | 11.9 | 7-16 |
| IgA | 2.11 | 3.04 | 0.7-4 |
| IgM | 0.29 | 0.84 | 0.4-2.3 |
| Cytokines, pg/mL | |||
| IL-10 | 85§ | 0 | 0-5 |
| sCD25 | 15740 | 1107 | 0-1900 |
| Autoantibodies | |||
| ANA | Negative∥ | Negative | NA |
| Anti-cardiolipin IgG, UFL/mL | < 0.5 | ND | 0-16 |
| Anti-cardiolipin IgM, UFL/mL | 3.9 | ND | 0-25 |
| Other laboratory test: direct Coombs test | Negative | ND | NA |
. | Patient . | Mother . | Reference value . |
|---|---|---|---|
| Total lymphocytes, × 109/L | 2.073 | 1.542 | 1-4 |
| T lymphocytes, % | |||
| CD3+ | 91 | 80 | 61-82 |
| CD3+CD4+ | 25 | 50 | 36-56 |
| CD3+CD8+ | 39 | 24 | 13-31 |
| CD4/CD8 ratio | 0.64 | 2.18 | 1-2.5 |
| CD3+TcR-αβ+ | 88 | 74 | 55-75 |
| CD3+TcR-γδ+ | 1 | 5 | 0-7 |
| TcR-αβ+CD4-CD8- (DN) | 25* | 1 | 0-2 |
| CD3+CD95+ | 81 | 65 | 60¶ |
| T-activation markers, % | |||
| CD3+CD38+ | 22 | 6 | 0-8 |
| CD3+HLA-DR+ | 18† | 6 | 0-10 |
| CD19+ B lymphocytes, % | 5 | 9 | 5-18 |
| CD16+CD56+CD3-NK lymphocytes, % | 3 | 10 | 3-18 |
| Immunoglobulins, g/L | |||
| IgG | 17.6‡ | 11.9 | 7-16 |
| IgA | 2.11 | 3.04 | 0.7-4 |
| IgM | 0.29 | 0.84 | 0.4-2.3 |
| Cytokines, pg/mL | |||
| IL-10 | 85§ | 0 | 0-5 |
| sCD25 | 15740 | 1107 | 0-1900 |
| Autoantibodies | |||
| ANA | Negative∥ | Negative | NA |
| Anti-cardiolipin IgG, UFL/mL | < 0.5 | ND | 0-16 |
| Anti-cardiolipin IgM, UFL/mL | 3.9 | ND | 0-25 |
| Other laboratory test: direct Coombs test | Negative | ND | NA |
Reference values were obtained from 50 unrelated healthy adults.
NA indicates not applicable; ND, not done.
Percentages of DN T lymphocytes: 29% in January 1990, 35% in March 1991, 23% in February 1995, 21% in October 2000, 23% in September 2003.
Percentages of CD3+HLA-DR+: 34% in February 1990, 20% in March 1991, 22% in March 1992, 17% in February 1995, 23% in February 1998, 12% in September 2003.
IgG concentrations: 50.6 g/L in January 1990; 40.9 g/L in March 1991; 32.2 g/L in March 1992; 28.4 g/L in February 1993; 26.4 g/L in February 1995; 23.3 g/L in January 1996; 21.0 g/L in February 1998; 19.1 g/L in October 2000; 26.2 g/L in September 2003.
IL-10 concentration: 96 pg/mL in September 2003.
ANA: 1/5120 in February 1993, 1/1280 in February 1995, negative in February 1998, 1/40 in September 2003.
Percentage of CD3+CD95+ in one healthy control.