Table 3. Serum chemistries of wild-type... | American Society of Hematology

Table 3.

Serum chemistries of wild-type and eosinophil lineage–ablated mice infected withS mansoni

Mouse strain/wk of infection	ALT, U/L	Fold ↑	AST, U/L	Fold ↑	Alk phos, U/L	CK, U/L	LD, U/L
BALB/c
0	46.8 ± 6.5	1.0	78.3 ± 5.3	1.0	94.8 ± 3.7	427 ± 114	581 ± 59
8	217 ± 29*	4.6†	202 ± 20*	2.6†	98.5 ± 4.8	602 ± 92	817 ± 62‡
11	124 ± 13‡	2.6†	132 ± 9‡	1.7†	115 ± 6	237 ± 33	579 ± 48
ΔdblGATA
0	33.4 ± 1.8	1.0	80.6 ± 10.5	1.0	88 ± 5.1	497 ± 137	640 ± 59
8	152 ± 44*	4.6†	163 ± 22‡	2.0†	54.5 ± 4.0	505 ± 87	896 ± 95‡
11	101 ± 11‡	3.0†	124 ± 12	1.5†	81 ± 6	218 ± 31	591 ± 62
C57BL/6
0	39 ± 3.5	1.0	63.5 ± 7.5	1.0	82 ± 5.3	184 ± 59	290 ± 32
8	194 ± 13*	5.0†	177 ± 12*	2.8†	56 ± 2	240 ± 22	457 ± 30
11	148 ± 16‡	3.8†	154 ± 17‡	2.4	78 ± 3	137 ± 23	410 ± 33
TgPHIL
0	58 ± 9	1.0	74 ± 9	1.0	115 ± 11	159 ± 37	252 ± 10
8	113 ± 9‡	1.9†	132 ± 8‡	1.8†	58 ± 4	219 ± 26	371 ± 20
11	93 ± 12	1.6†	111 ± 13	1.5†	73 ± 6	120 ± 24	253 ± 19

Mouse strain/wk of infection	ALT, U/L	Fold ↑	AST, U/L	Fold ↑	Alk phos, U/L	CK, U/L	LD, U/L
BALB/c
0	46.8 ± 6.5	1.0	78.3 ± 5.3	1.0	94.8 ± 3.7	427 ± 114	581 ± 59
8	217 ± 29*	4.6†	202 ± 20*	2.6†	98.5 ± 4.8	602 ± 92	817 ± 62‡
11	124 ± 13‡	2.6†	132 ± 9‡	1.7†	115 ± 6	237 ± 33	579 ± 48
ΔdblGATA
0	33.4 ± 1.8	1.0	80.6 ± 10.5	1.0	88 ± 5.1	497 ± 137	640 ± 59
8	152 ± 44*	4.6†	163 ± 22‡	2.0†	54.5 ± 4.0	505 ± 87	896 ± 95‡
11	101 ± 11‡	3.0†	124 ± 12	1.5†	81 ± 6	218 ± 31	591 ± 62
C57BL/6
0	39 ± 3.5	1.0	63.5 ± 7.5	1.0	82 ± 5.3	184 ± 59	290 ± 32
8	194 ± 13*	5.0†	177 ± 12*	2.8†	56 ± 2	240 ± 22	457 ± 30
11	148 ± 16‡	3.8†	154 ± 17‡	2.4	78 ± 3	137 ± 23	410 ± 33
TgPHIL
0	58 ± 9	1.0	74 ± 9	1.0	115 ± 11	159 ± 37	252 ± 10
8	113 ± 9‡	1.9†	132 ± 8‡	1.8†	58 ± 4	219 ± 26	371 ± 20
11	93 ± 12	1.6†	111 ± 13	1.5†	73 ± 6	120 ± 24	253 ± 19

Serum samples were taken from mice prior to infection (week 0, n = 8-13 mice) and at weeks 8 and 11 (n = 12-13 mice) after exposure to cercariae. Although elevations in serum ALT and AST were observed in all mice response to infection, no consistent differences were observed between wild type and eosinophil lineage—ablated mice.

Data are presented as plus or minus standard error of the mean.

ALT indicates alanine aminotransferase; AST, aspartate aminotransferase; Alk phos, alkaline phosphatase; CK, creatine kinase; and LD, lactate dehydrogenase.

P < .01 versus uninfected mice of the same genotype.

†

Ratios of infected to uninfected values at points indicated.

‡

P < .05 versus uninfected mice of the same genotype.

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