Features of somatic mutations in the BCL6 major mutation cluster (MMC) region (858-bp sequence at 5′ of BCL6 first intron was analyzed) in gastric lymphoma
Feature . | Value . |
|---|---|
| Frequency × 10-3/bp, range* | 1.17-24.48 |
| Single bp substitutions | 170 |
| Deletions | 12 |
| Insertions | 10 |
| Transitions/transversions† | 1.63 |
| Strand polarity†‡ | 1.57 |
| RGYW/WRCY bias§ | 1.43 |
Feature . | Value . |
|---|---|
| Frequency × 10-3/bp, range* | 1.17-24.48 |
| Single bp substitutions | 170 |
| Deletions | 12 |
| Insertions | 10 |
| Transitions/transversions† | 1.63 |
| Strand polarity†‡ | 1.57 |
| RGYW/WRCY bias§ | 1.43 |
The overall frequency of mutations in the BCL6 MMC region in gastric lymphoma is extrapolated from the frequency of mutated cases occurring in this group (24 of 43 cases; 55.8%).
The frequency of substitutions affecting each base was corrected for the base composition of the region analyzed.
Values designate the ratio of A → N vs T → N substitutions.
Normalized frequency of mutated G bases occurring in the context of an RGYW (A/G G C/T A/T) and C bases in its inverse compliment WRCY (A/T A/G C C/T) motif.