Table 3. Mutational analysis of IGHV,... | American Society of Hematology

Table 3.

Mutational analysis of IGHV, c-MYC, RhoH/TTF, PAX5, and PIM1 in classic HL

	IGH gene analysis									Mutation position
Patient	*IGHV*	*IGHD*	*IGHJ*	Mutation, %	Functional status	c-MYC exon 1	c-MYC exon 2	*RhoH/TTF*	*PIM1*	*PAX5*
cHL 1	1-69	3-09 + 1-26	4	24.1	+	-	-	-	-	-
cHL 2	4-39	NA	4	7.69	+	-	-	-	G1255A, G1554A	-
cHL 3	3-33	3-03	6b	6.77	+	-	-	-	-	-
cHL 4	4-39	NA	5b	13.6	+	-	-	-	-	-
cHL 5	3-11	NA	6c	1.24	Out-of-frame	G2471A, G2851A	-	-	-	-
cHL 6	1-69	NA	6b	14.4	+	-	-	-	-	-
cHL 7	4-39	3-22	4b	0	+	T2486C, A2528G, T2771A, G2805A, T2868A, T3152C, T3268C, A3305T, insT3426	-	NA	-	C718T, C871T
cHL 8	NA	ND	ND	ND	ND	T2456G, G2709T, A2730G, C2732A, C2770T, C2778G, T2868C, G2886A, del38bp 2891-2928, G2933A	A4692G	-	-	-
cHL 9	5-a	6-13	6c	0	+	A2490G, C3319T	-	-	-	T788C, G847A, C848G, C853A, G971A, del3bp 1045-1047, G1425A

	IGH gene analysis									Mutation position
Patient	*IGHV*	*IGHD*	*IGHJ*	Mutation, %	Functional status	c-MYC exon 1	c-MYC exon 2	*RhoH/TTF*	*PIM1*	*PAX5*
cHL 1	1-69	3-09 + 1-26	4	24.1	+	-	-	-	-	-
cHL 2	4-39	NA	4	7.69	+	-	-	-	G1255A, G1554A	-
cHL 3	3-33	3-03	6b	6.77	+	-	-	-	-	-
cHL 4	4-39	NA	5b	13.6	+	-	-	-	-	-
cHL 5	3-11	NA	6c	1.24	Out-of-frame	G2471A, G2851A	-	-	-	-
cHL 6	1-69	NA	6b	14.4	+	-	-	-	-	-
cHL 7	4-39	3-22	4b	0	+	T2486C, A2528G, T2771A, G2805A, T2868A, T3152C, T3268C, A3305T, insT3426	-	NA	-	C718T, C871T
cHL 8	NA	ND	ND	ND	ND	T2456G, G2709T, A2730G, C2732A, C2770T, C2778G, T2868C, G2886A, del38bp 2891-2928, G2933A	A4692G	-	-	-
cHL 9	5-a	6-13	6c	0	+	A2490G, C3319T	-	-	-	T788C, G847A, C848G, C853A, G971A, del3bp 1045-1047, G1425A

Numbering according to GenBank accession numbers X00364 (c-MYC), AF386789 (RhoH/TTF), AF386792 (PIM1), and AF386791 (PAX5).

NA indicates not available; ND, not determined; del, deletion; -, germline; +, productive rearrangement; and ins, insertion.