Mutational analysis of IGHV, c-MYC, RhoH/TTF, PAX5, and PIM1 in NLPHL
. | IGH gene analysis . | . | . | . | . | Mutation position . | . | . | . | . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Patient . | IGHV . | IGHD . | IGHJ . | Mutation, % . | Functional status . | c-MYC exon 1 . | c-MYC exon 2 . | RhoH/TTF . | PIM1 . | PAX5 . | ||||||||
| NLPHL 1 | 3-30 | 6-06 | 5b | 25.2 | + | - | - | - | - | - | ||||||||
| NLPHL 2 | 3-33 | 5-24 + 5-18 | 6b | 7.14 | + | - | - | G261A; G395A | G1323A | G729A; C1026G; G1425C; C1436G | ||||||||
| NLPHL 3 | 4-34 | 2-15 | 4b | 4.54 | Crippled | - | G4580T | - | - | C674T; C848T; del18bp (1317-1334); C1357G | ||||||||
| NLPHL 4 | 4-34 | 3-03 | 6b | 12.3 | + | - | T4312A | - | - | NA | ||||||||
| NLPHL 5 | 3-07 | 4-17 + 3-03 + 7-27 | 6b | 6.73 | + | - | NA | - | NA | G910A; C953T; C962T; G1070C; G1342A | ||||||||
| NLPHL 6 | 4-59 | 4-17 | 4b | 9.18 | + | - | - | - | - | C731T; T805G | ||||||||
| NLPHL 7 | NA | ND | ND | ND | ND | G3019A; G3056A | - | - | NA | A762G | ||||||||
| NLPHL 8 | 3-33 | D5 | 6c | 5.36 | + | delG3028 | - | NA | T1365C, C1682T | G847A, C958T | ||||||||
| NLPHL 9 | 4-39 | D4 | 4b | 5.94 | + | - | G4650A | - | del1137-1140 | C674G, T771G, C853G, A1033G | ||||||||
| NLPHL 10 | 3-74 | 2-02 | 4b | 9.33 | + | - | - | - | - | - | ||||||||
. | IGH gene analysis . | . | . | . | . | Mutation position . | . | . | . | . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Patient . | IGHV . | IGHD . | IGHJ . | Mutation, % . | Functional status . | c-MYC exon 1 . | c-MYC exon 2 . | RhoH/TTF . | PIM1 . | PAX5 . | ||||||||
| NLPHL 1 | 3-30 | 6-06 | 5b | 25.2 | + | - | - | - | - | - | ||||||||
| NLPHL 2 | 3-33 | 5-24 + 5-18 | 6b | 7.14 | + | - | - | G261A; G395A | G1323A | G729A; C1026G; G1425C; C1436G | ||||||||
| NLPHL 3 | 4-34 | 2-15 | 4b | 4.54 | Crippled | - | G4580T | - | - | C674T; C848T; del18bp (1317-1334); C1357G | ||||||||
| NLPHL 4 | 4-34 | 3-03 | 6b | 12.3 | + | - | T4312A | - | - | NA | ||||||||
| NLPHL 5 | 3-07 | 4-17 + 3-03 + 7-27 | 6b | 6.73 | + | - | NA | - | NA | G910A; C953T; C962T; G1070C; G1342A | ||||||||
| NLPHL 6 | 4-59 | 4-17 | 4b | 9.18 | + | - | - | - | - | C731T; T805G | ||||||||
| NLPHL 7 | NA | ND | ND | ND | ND | G3019A; G3056A | - | - | NA | A762G | ||||||||
| NLPHL 8 | 3-33 | D5 | 6c | 5.36 | + | delG3028 | - | NA | T1365C, C1682T | G847A, C958T | ||||||||
| NLPHL 9 | 4-39 | D4 | 4b | 5.94 | + | - | G4650A | - | del1137-1140 | C674G, T771G, C853G, A1033G | ||||||||
| NLPHL 10 | 3-74 | 2-02 | 4b | 9.33 | + | - | - | - | - | - | ||||||||