Adult β-globin expression measured in the peripheral blood of heterozygotic animals
. | WT . | ΔLCR . | ΔHS-62.5, ΔLCR . | ΔHS-62.5 →ΔLCR . | Δ-62.5 . | Δ3′HS1 . | Δ-62.5, Δ3′HS1 . |
|---|---|---|---|---|---|---|---|
| 100-cell pools (n) | 0.97 ± 0.02 (4) | 0.05 ± 0.01 (3) | 0.04 ± 0.01 (3) | 0.04 ± 0.0 (3) | 1.06 ± 0.02 (8) | 1.04 ± 0.04 (8) | 1.02 ± 0.02 (8) |
| Single cells (n, no. cells analyzed) | 1.00 ± 0.12 (1.8) | 0.03 ± 0.01* (4, 26) | 0.05 ± 0.03 (1, 10) | 0.04 ± 0.02 (4, 16) | 1.15 ± 0.09 (3, 12) | 1.10 ± 0.08 (3, 11) | 1.02 ± 0.11 (1, 16) |
. | WT . | ΔLCR . | ΔHS-62.5, ΔLCR . | ΔHS-62.5 →ΔLCR . | Δ-62.5 . | Δ3′HS1 . | Δ-62.5, Δ3′HS1 . |
|---|---|---|---|---|---|---|---|
| 100-cell pools (n) | 0.97 ± 0.02 (4) | 0.05 ± 0.01 (3) | 0.04 ± 0.01 (3) | 0.04 ± 0.0 (3) | 1.06 ± 0.02 (8) | 1.04 ± 0.04 (8) | 1.02 ± 0.02 (8) |
| Single cells (n, no. cells analyzed) | 1.00 ± 0.12 (1.8) | 0.03 ± 0.01* (4, 26) | 0.05 ± 0.03 (1, 10) | 0.04 ± 0.02 (4, 16) | 1.15 ± 0.09 (3, 12) | 1.10 ± 0.08 (3, 11) | 1.02 ± 0.11 (1, 16) |
Values are expressed as the ratio of expression from a mutant D allele to that of a wild-type S allele measured in either 100-cell pools of reticulocytes or in individual reticulocytes ± SD.
Historical data.36