Details of the 11 patients with documented sperm production and results of their semen analyses
UPN . | Diagnosis . | Conditioning regimen . | Age at HSCT, y . | Time interval, y . | Chronic GvHD . | Spermatogenesis type . | Motility, % (normal)* . | Morphology, % (normal)† . | Paternity (time after HSCT, y)‡ . |
|---|---|---|---|---|---|---|---|---|---|
| 259 | SAA | Cy | 13 | 18 | 0 | Normozoospermic | 59 (yes) | 12 (no) | Yes (16) |
| 340 | SAA | Cy | 25 | 15 | 0 | Normozoospermic | 57 (yes) | 14 (no) | Yes (5) |
| 438 | AML | TBI, Cy, ETOP | 19 | 12 | 0 | Normozoospermic | 70 (yes) | 13 (no) | Yes (9 and 11) |
| 732 | AML | Cy, Bu | 42 | 5 | 0 | Oligozoospermia | 69 (yes) | 5 (no) | No |
| 308 | ALL | TBI, Cy | 5 | 17 | 0 | Severe oligozoospermia | 70 (yes) | 19 (no) | No |
| 334 | AML | TBI, Cy, ETOP | 14 | 16 | Extensive | Severe oligozoospermia | 40 (no) | 2 (no) | No |
| 436 | AML | TBI, Cy, ETOP | 13 | 12 | 0 | Severe oligozoospermia | 66 (yes) | 22 (no) | No |
| 440 | SAA | Cy | 18 | 12 | Limited | Severe oligozoospermia | 44 (no) | 3 (no) | No |
| 509 | AML | TBI, Cy, ETOP | 25 | 9 | 0 | Severe oligozoospermia | 6 (no) | 5§ (no) | No |
| 860 | AML | TBI, Cy, ETOP | 19 | 3 | 0 | Severe oligozoospermia | 75 (yes) | 18 (no) | No |
| 241 | AML | TBI, Cy | 19 | 19 | 0 | Cryptozoospermic | 0 (no) | 0 (no) | No |
UPN . | Diagnosis . | Conditioning regimen . | Age at HSCT, y . | Time interval, y . | Chronic GvHD . | Spermatogenesis type . | Motility, % (normal)* . | Morphology, % (normal)† . | Paternity (time after HSCT, y)‡ . |
|---|---|---|---|---|---|---|---|---|---|
| 259 | SAA | Cy | 13 | 18 | 0 | Normozoospermic | 59 (yes) | 12 (no) | Yes (16) |
| 340 | SAA | Cy | 25 | 15 | 0 | Normozoospermic | 57 (yes) | 14 (no) | Yes (5) |
| 438 | AML | TBI, Cy, ETOP | 19 | 12 | 0 | Normozoospermic | 70 (yes) | 13 (no) | Yes (9 and 11) |
| 732 | AML | Cy, Bu | 42 | 5 | 0 | Oligozoospermia | 69 (yes) | 5 (no) | No |
| 308 | ALL | TBI, Cy | 5 | 17 | 0 | Severe oligozoospermia | 70 (yes) | 19 (no) | No |
| 334 | AML | TBI, Cy, ETOP | 14 | 16 | Extensive | Severe oligozoospermia | 40 (no) | 2 (no) | No |
| 436 | AML | TBI, Cy, ETOP | 13 | 12 | 0 | Severe oligozoospermia | 66 (yes) | 22 (no) | No |
| 440 | SAA | Cy | 18 | 12 | Limited | Severe oligozoospermia | 44 (no) | 3 (no) | No |
| 509 | AML | TBI, Cy, ETOP | 25 | 9 | 0 | Severe oligozoospermia | 6 (no) | 5§ (no) | No |
| 860 | AML | TBI, Cy, ETOP | 19 | 3 | 0 | Severe oligozoospermia | 75 (yes) | 18 (no) | No |
| 241 | AML | TBI, Cy | 19 | 19 | 0 | Cryptozoospermic | 0 (no) | 0 (no) | No |
Cy indicates cyclophosphamide; ETOP, etoposide; Bu, busulfan.
Normal motility: when at least > 50% of spermatozoa were motile.
Normal when > 25% of the spermatozoa had a normal morphology.
Paternity after transplantation and interval time between HSCT and paternity in years; 1 patient fathered 2 children.
In only 20 sperm.