Adverse events according to treatment arm
. | Percentage of adverse events (% grade 3-4) . | . | . | . | ||
|---|---|---|---|---|---|---|
. | Arm A . | Arm B . | Arm C . | P . | ||
| Peripheral neuropathy | 8 (1) | 15 (2) | 68 (7) | < .001 | ||
| Fatigue | 3 (1) | 7 (2) | 34 (6) | < .001 | ||
| Constipation | 0 | 2 (0) | 20 (1) | < .001 | ||
| Neutropenia | 0 | 2 (1) | 7 (6) | .001 | ||
| Cardiac | 0 | 1 (0) | 4 (1) | .04 | ||
| Thrombosis | 2 (1) | 1 (1) | 4 (2) | NS | ||
| Thrombocytopenia | 2 (2) | 2 (2) | 3 (3) | NS | ||
| Anemia | 2 (1) | 2 (1) | 2 (2) | NS | ||
| Infection | 17 (4) | 24 (7) | 24 (6) | NS | ||
| Mood change | 2 (0) | 4 (0) | 5 (1) | NS | ||
| Renal | 2 (1) | 1 (1) | 3 (2) | NS | ||
| Osteonecrosis of the jaw | 0 | 1 | 1 | NS | ||
| Nausea | 2 (0) | 3 (1) | 2 (0) | NS | ||
. | Percentage of adverse events (% grade 3-4) . | . | . | . | ||
|---|---|---|---|---|---|---|
. | Arm A . | Arm B . | Arm C . | P . | ||
| Peripheral neuropathy | 8 (1) | 15 (2) | 68 (7) | < .001 | ||
| Fatigue | 3 (1) | 7 (2) | 34 (6) | < .001 | ||
| Constipation | 0 | 2 (0) | 20 (1) | < .001 | ||
| Neutropenia | 0 | 2 (1) | 7 (6) | .001 | ||
| Cardiac | 0 | 1 (0) | 4 (1) | .04 | ||
| Thrombosis | 2 (1) | 1 (1) | 4 (2) | NS | ||
| Thrombocytopenia | 2 (2) | 2 (2) | 3 (3) | NS | ||
| Anemia | 2 (1) | 2 (1) | 2 (2) | NS | ||
| Infection | 17 (4) | 24 (7) | 24 (6) | NS | ||
| Mood change | 2 (0) | 4 (0) | 5 (1) | NS | ||
| Renal | 2 (1) | 1 (1) | 3 (2) | NS | ||
| Osteonecrosis of the jaw | 0 | 1 | 1 | NS | ||
| Nausea | 2 (0) | 3 (1) | 2 (0) | NS | ||
NS indicates not significant.