Cardiac index and vascular resistance 30 minutes after infusion of CFH
. | Cardiac index . | Femoral arterial pressure . | Estimated peripheral vascular resistance . | Mean arterial pressure . | Peripheral vascular resistance . |
|---|---|---|---|---|---|
| Saline | 1.05 ± 0.09 | 1.01 ± 0.06 | 1.01 ± 0.02 | 0.98 ± 0.04 | 0.93 ± 0.06 |
| Concentration | |||||
| PBH4 | 0.84 ± 0.07* | 1.00 ± 0.06 | 1.20 ± 0.09 | 1.11 ± 0.07* | 1.31 ± 0.11 |
| PBH | 0.78 ± 0.10* | 1.09 ± 0.09 | 1.42 ± 0.24* | 1.14 ± 0.05* | 1.46 ± 0.13 |
| Molecular configuration | |||||
| ααHb | 0.78 ± 0.13*† | 1.06 ± 0.04 | 1.38 ± 0.23*† | 1.11 ± 0.11* | 1.43 ± 0.20 |
| PBH4 | 0.84 ± 0.07*† | 1.00 ± 0.06 | 1.20 ± 0.09 | 1.11 ± 0.07* | 1.31 ± 0.11 |
| MP4 | 1.01 ± 0.07 | 0.99 ± 0.04 | 0.98 ± 0.09 | 1.08 ± 0.06* | 1.07 ± 0.09 |
. | Cardiac index . | Femoral arterial pressure . | Estimated peripheral vascular resistance . | Mean arterial pressure . | Peripheral vascular resistance . |
|---|---|---|---|---|---|
| Saline | 1.05 ± 0.09 | 1.01 ± 0.06 | 1.01 ± 0.02 | 0.98 ± 0.04 | 0.93 ± 0.06 |
| Concentration | |||||
| PBH4 | 0.84 ± 0.07* | 1.00 ± 0.06 | 1.20 ± 0.09 | 1.11 ± 0.07* | 1.31 ± 0.11 |
| PBH | 0.78 ± 0.10* | 1.09 ± 0.09 | 1.42 ± 0.24* | 1.14 ± 0.05* | 1.46 ± 0.13 |
| Molecular configuration | |||||
| ααHb | 0.78 ± 0.13*† | 1.06 ± 0.04 | 1.38 ± 0.23*† | 1.11 ± 0.11* | 1.43 ± 0.20 |
| PBH4 | 0.84 ± 0.07*† | 1.00 ± 0.06 | 1.20 ± 0.09 | 1.11 ± 0.07* | 1.31 ± 0.11 |
| MP4 | 1.01 ± 0.07 | 0.99 ± 0.04 | 0.98 ± 0.09 | 1.08 ± 0.06* | 1.07 ± 0.09 |
Parameters normalized to baseline. Data are shown as mean ± STD (except for peripheral vascular resistance); normalized to baseline (parameter 30 minutes after CFH infusion divided by its value at baseline conditions, thus 1.1 would equal a 10% increase while 0.9 would denote a 10% decrease from baseline). Cardiac index was calculated as cardiac output divided by animal body weight. Estimated peripheral vascular resistance was calculated as femoral arterial pressure divided by cardiac index. Mean arterial pressure was measured from the carotid artery (data obtained from NO measurement experiments). Peripheral vascular resistance was calculated as the mean arterial pressure divided by CI (mean ± estimated uncertainty). Uncertainty was determined by the mean and standard deviation of the parameters
P < .05 relative to saline
P < .05 relative to MP4