Inhibition of proinflammatory cytokines by ligation of AC receptors
. | CD11b . | Avβ5 . | CD11b and αvβ5 . |
|---|---|---|---|
| TNF-α | 42.7 ± 25.9 (11) | 8.9 ± 5.5 (9) | 39.2 ± 27.3 (6) |
| IL-6 | 44.9 ± 27.1 (12) | 18.1 ± 13.1 (5) | 41.4 ± 36.1 (3) |
| IL-1β | 61.1 ± 21.6 (9) | 16.6 ± 10.5 (3) | 51.5 ± 16.9 (3) |
. | CD11b . | Avβ5 . | CD11b and αvβ5 . |
|---|---|---|---|
| TNF-α | 42.7 ± 25.9 (11) | 8.9 ± 5.5 (9) | 39.2 ± 27.3 (6) |
| IL-6 | 44.9 ± 27.1 (12) | 18.1 ± 13.1 (5) | 41.4 ± 36.1 (3) |
| IL-1β | 61.1 ± 21.6 (9) | 16.6 ± 10.5 (3) | 51.5 ± 16.9 (3) |
Percent inhibition in cytokine production by CD11b-, αvβ5-, or αvβ5/CD11b-ApoS and LPS stimulated, compared to control (Ig), DCs, was calculated for all donors tested. Data are expressed as the average ± SD, with the number of averaged values shown in parentheses.