Frequencies of specific cytogenetic abnormalities in different age groups
Cytogenetic abnormality . | 60-69 y . | 70-79 y . | 80 y or older . |
|---|---|---|---|
| Normal karyotype | 109 (45) | 50 (45) | 2 (33) |
| Unbalanced* | |||
| +4 | 4 (2) | 1 (1) | 0 (0) |
| -5/del(5q) | 35 (14) | 21 (19) | 1 (17) |
| -5 | 10 (4) | 6 (5) | 0 (0) |
| del(5q) | 25 (10) | 15 (13) | 1 (17) |
| -7/del(7q) | 36 (15) | 16 (14) | 0 (0) |
| -7 | 12 (5) | 11 (10) | 0 (0) |
| del(7q) | 24 (10) | 5 (4) | 0 (0) |
| +8 | 32 (13) | 14 (13) | 1 (17) |
| Noncomplex | 17 (7) | 4 (4) | 1 (17) |
| Complex | 15 (6) | 10 (9) | 0 (0) |
| +11 | 13 (5) | 7 (6) | 0 (0) |
| Noncomplex | 5 (2) | 1 (1) | 0 (0) |
| Complex | 8 (3) | 6 (5) | 0 (0) |
| +13 | 12 (5) | 4 (4) | 1 (17) |
| del(13q) | 9 (4) | 6 (5) | 0 (0) |
| +14 | 5 (2) | 4 (4) | 0 (0) |
| -17/del(17p) | 16 (7) | 8 (7) | 1 (17) |
| -17 | 8 (3) | 5 (4) | 1 (17) |
| del(17p) | 8 (3) | 3 (3) | 0 (0) |
| -18 | 5 (2) | 4 (4) | 0 (0) |
| -20/del(20q) | 17 (7) | 6 (5) | 0 (0) |
| -20 | 6 (2) | 2 (2) | 0 (0) |
| del(20q) | 11 (5) | 4 (4) | 0 (0) |
| +21 | 12 (5) | 5 (4) | 0 (0) |
| +22 | 12 (5) | 5 (4) | 0 (0) |
| Balanced† | |||
| t(8;21) | 7 (3) | 5 (4) | 0 (0) |
| t(11q23) | 7 (3) | 4 (4) | 0 (0) |
| t(15;17) | 7 (3) | 4 (4) | 0 (0) |
| inv(16)/t(16;16) | 12 (5) | 2 (2) | 0 (0) |
| Other‡ | |||
| abn(3q) | 9 (4) | 5 (4) | 0 (0) |
| abn(12p) | 10 (4) | 14 (13) | 1 (17) |
| Complex | |||
| 3 or more unrelated | 37 (15) | 23 (21) | 1 (17) |
| 5 or more unrelated | 28 (12) | 15 (13) | 1 (17) |
| Total | 243 (100) | 112 (100) | 6 (100) |
Cytogenetic abnormality . | 60-69 y . | 70-79 y . | 80 y or older . |
|---|---|---|---|
| Normal karyotype | 109 (45) | 50 (45) | 2 (33) |
| Unbalanced* | |||
| +4 | 4 (2) | 1 (1) | 0 (0) |
| -5/del(5q) | 35 (14) | 21 (19) | 1 (17) |
| -5 | 10 (4) | 6 (5) | 0 (0) |
| del(5q) | 25 (10) | 15 (13) | 1 (17) |
| -7/del(7q) | 36 (15) | 16 (14) | 0 (0) |
| -7 | 12 (5) | 11 (10) | 0 (0) |
| del(7q) | 24 (10) | 5 (4) | 0 (0) |
| +8 | 32 (13) | 14 (13) | 1 (17) |
| Noncomplex | 17 (7) | 4 (4) | 1 (17) |
| Complex | 15 (6) | 10 (9) | 0 (0) |
| +11 | 13 (5) | 7 (6) | 0 (0) |
| Noncomplex | 5 (2) | 1 (1) | 0 (0) |
| Complex | 8 (3) | 6 (5) | 0 (0) |
| +13 | 12 (5) | 4 (4) | 1 (17) |
| del(13q) | 9 (4) | 6 (5) | 0 (0) |
| +14 | 5 (2) | 4 (4) | 0 (0) |
| -17/del(17p) | 16 (7) | 8 (7) | 1 (17) |
| -17 | 8 (3) | 5 (4) | 1 (17) |
| del(17p) | 8 (3) | 3 (3) | 0 (0) |
| -18 | 5 (2) | 4 (4) | 0 (0) |
| -20/del(20q) | 17 (7) | 6 (5) | 0 (0) |
| -20 | 6 (2) | 2 (2) | 0 (0) |
| del(20q) | 11 (5) | 4 (4) | 0 (0) |
| +21 | 12 (5) | 5 (4) | 0 (0) |
| +22 | 12 (5) | 5 (4) | 0 (0) |
| Balanced† | |||
| t(8;21) | 7 (3) | 5 (4) | 0 (0) |
| t(11q23) | 7 (3) | 4 (4) | 0 (0) |
| t(15;17) | 7 (3) | 4 (4) | 0 (0) |
| inv(16)/t(16;16) | 12 (5) | 2 (2) | 0 (0) |
| Other‡ | |||
| abn(3q) | 9 (4) | 5 (4) | 0 (0) |
| abn(12p) | 10 (4) | 14 (13) | 1 (17) |
| Complex | |||
| 3 or more unrelated | 37 (15) | 23 (21) | 1 (17) |
| 5 or more unrelated | 28 (12) | 15 (13) | 1 (17) |
| Total | 243 (100) | 112 (100) | 6 (100) |
Values indicates number of patients, with percentage in parentheses. Patients may be counted more than once due to the coexistence of more than 1 cytogenetic abnormality in the leukemic clone.
In the absence of t(8;21), t(11q23), t(15;17), or inv(16)/t(16;16).
Irrespective of karyotype complexity.
Including cases with unbalanced or balanced abnormalities.