Frequency and characteristics of specific cytogenetic abnormalities among 361 AML patients older than 60
. | No. of patients (%) . | . | . | . | . | ||||
|---|---|---|---|---|---|---|---|---|---|
| Cytogenetic abnormality . | Total . | 1 abnormality . | 2 abnormalities . | 3 or more abnormalities . | 5 or more abnormalities . | ||||
| Normal karyotype | 161 (45) | NA | NA | NA | NA | ||||
| -5/del(5q) | 57 (16) | 2 (4) | 4 (7) | 51 (89) | 39 (68) | ||||
| -5 | 16 (4) | 0 (0) | 0 (0) | 16 (100) | 15 (94) | ||||
| del(5q)* | 41 (11) | 2 (5) | 4 (10) | 35 (85) | 24 (59) | ||||
| Balanced | 3 | 0 | 0 | 3 | 2 | ||||
| -7/del(7q) | 52 (14) | 9 (17) | 11 (21) | 32 (62) | 25 (48) | ||||
| -7 | 23 (6) | 2 (9) | 5 (22) | 16 (70) | 12 (52) | ||||
| del(7q)† | 29 (8) | 7 (24) | 4 (14) | 18 (62) | 13 (45) | ||||
| Balanced | 3 | 0 | 1 | 0 | 2 | ||||
| +8 | 47 (13) | 18 (38) | 4 (9) | 25 (53) | 18 (38) | ||||
| Balanced | 9 | 0 | 3 | 6 | 2 | ||||
| -17/del(17p) | 25 (7) | 0 (0) | 1 (4) | 24 (96) | 24 (96) | ||||
| Balanced | 1 | 0 | 1 | 0 | 0 | ||||
| abn(12p) | 25 (7) | 3 (12) | 2 (8) | 20 (80) | 15 (60) | ||||
| Balanced | 3 | 0 | 1 | 2 | 1 | ||||
| -20/del(20q) | 23 (6) | 3 (13) | 2 (9) | 18 (78) | 13 (57) | ||||
| Balanced | 4 | 0 | 0 | 4 | 1 | ||||
| +11 | 20 (6) | 4 (20) | 2 (10) | 14 (70) | 13 (65) | ||||
| +13 | 17 (5) | 8 (47) | 0 (0) | 9 (53) | 8 (47) | ||||
| +21 | 17 (5) | 2 (12) | 2 (12) | 13 (76) | 8 (47) | ||||
| Balanced | 1 | 0 | 0 | 1 | 0 | ||||
| +22 | 17 (5) | 0 (0) | 1 (6) | 16 (94) | 12 (71) | ||||
| Balanced | 3 | 0 | 1 | 2 | 1 | ||||
| del(13q) | 15 (4) | 1 (7) | 1 (7) | 13 (87) | 12 (80) | ||||
| Balanced | 1 | 0 | 0 | 0 | 1 | ||||
| abn(3q) | 14 (4) | 1 (7) | 1 (7) | 12 (86) | 10 (71) | ||||
| inv(16) | 14 (4) | 9 (64) | 3 (21) | 2 (14) | 0 (0) | ||||
| t(8;21) | 12 (3) | 6 (50) | 4 (33) | 2 (17) | 0 (0) | ||||
| t(11q23) | 11 (3) | 3 (27) | 3 (27) | 5 (45) | 3 (27) | ||||
| t(9;11) | 5 (1) | 2 (40) | 2 (40) | 1 (20) | 0 (0) | ||||
| t(11;various) | 6 (2) | 1 (17) | 1 (17) | 4 (67) | 3 (50) | ||||
| t(15;17) | 11 (3) | 7 (64) | 3 (27) | 1 (9) | 0 (0) | ||||
| +14 | 9 (2) | 0 (0) | 1 (11) | 8 (89) | 6 (67) | ||||
| -18 | 9 (2) | 0 (0) | 0 (0) | 9 (100) | 9 (100) | ||||
| -Y | 8 (2) | 1 (13) | 2 (25) | 5 (63) | 2 (25) | ||||
| Balanced | 4 | 0 | 2 | 2 | 0 | ||||
| +4 | 5 (1) | 1 (20) | 0 (0) | 4 (80) | 4 (80) | ||||
| del(11q) | 5 (1) | 0 (0) | 1 (20) | 4 (80) | 3 (60) | ||||
| Balanced | 2 | 0 | 0 | 2 | 1 | ||||
. | No. of patients (%) . | . | . | . | . | ||||
|---|---|---|---|---|---|---|---|---|---|
| Cytogenetic abnormality . | Total . | 1 abnormality . | 2 abnormalities . | 3 or more abnormalities . | 5 or more abnormalities . | ||||
| Normal karyotype | 161 (45) | NA | NA | NA | NA | ||||
| -5/del(5q) | 57 (16) | 2 (4) | 4 (7) | 51 (89) | 39 (68) | ||||
| -5 | 16 (4) | 0 (0) | 0 (0) | 16 (100) | 15 (94) | ||||
| del(5q)* | 41 (11) | 2 (5) | 4 (10) | 35 (85) | 24 (59) | ||||
| Balanced | 3 | 0 | 0 | 3 | 2 | ||||
| -7/del(7q) | 52 (14) | 9 (17) | 11 (21) | 32 (62) | 25 (48) | ||||
| -7 | 23 (6) | 2 (9) | 5 (22) | 16 (70) | 12 (52) | ||||
| del(7q)† | 29 (8) | 7 (24) | 4 (14) | 18 (62) | 13 (45) | ||||
| Balanced | 3 | 0 | 1 | 0 | 2 | ||||
| +8 | 47 (13) | 18 (38) | 4 (9) | 25 (53) | 18 (38) | ||||
| Balanced | 9 | 0 | 3 | 6 | 2 | ||||
| -17/del(17p) | 25 (7) | 0 (0) | 1 (4) | 24 (96) | 24 (96) | ||||
| Balanced | 1 | 0 | 1 | 0 | 0 | ||||
| abn(12p) | 25 (7) | 3 (12) | 2 (8) | 20 (80) | 15 (60) | ||||
| Balanced | 3 | 0 | 1 | 2 | 1 | ||||
| -20/del(20q) | 23 (6) | 3 (13) | 2 (9) | 18 (78) | 13 (57) | ||||
| Balanced | 4 | 0 | 0 | 4 | 1 | ||||
| +11 | 20 (6) | 4 (20) | 2 (10) | 14 (70) | 13 (65) | ||||
| +13 | 17 (5) | 8 (47) | 0 (0) | 9 (53) | 8 (47) | ||||
| +21 | 17 (5) | 2 (12) | 2 (12) | 13 (76) | 8 (47) | ||||
| Balanced | 1 | 0 | 0 | 1 | 0 | ||||
| +22 | 17 (5) | 0 (0) | 1 (6) | 16 (94) | 12 (71) | ||||
| Balanced | 3 | 0 | 1 | 2 | 1 | ||||
| del(13q) | 15 (4) | 1 (7) | 1 (7) | 13 (87) | 12 (80) | ||||
| Balanced | 1 | 0 | 0 | 0 | 1 | ||||
| abn(3q) | 14 (4) | 1 (7) | 1 (7) | 12 (86) | 10 (71) | ||||
| inv(16) | 14 (4) | 9 (64) | 3 (21) | 2 (14) | 0 (0) | ||||
| t(8;21) | 12 (3) | 6 (50) | 4 (33) | 2 (17) | 0 (0) | ||||
| t(11q23) | 11 (3) | 3 (27) | 3 (27) | 5 (45) | 3 (27) | ||||
| t(9;11) | 5 (1) | 2 (40) | 2 (40) | 1 (20) | 0 (0) | ||||
| t(11;various) | 6 (2) | 1 (17) | 1 (17) | 4 (67) | 3 (50) | ||||
| t(15;17) | 11 (3) | 7 (64) | 3 (27) | 1 (9) | 0 (0) | ||||
| +14 | 9 (2) | 0 (0) | 1 (11) | 8 (89) | 6 (67) | ||||
| -18 | 9 (2) | 0 (0) | 0 (0) | 9 (100) | 9 (100) | ||||
| -Y | 8 (2) | 1 (13) | 2 (25) | 5 (63) | 2 (25) | ||||
| Balanced | 4 | 0 | 2 | 2 | 0 | ||||
| +4 | 5 (1) | 1 (20) | 0 (0) | 4 (80) | 4 (80) | ||||
| del(11q) | 5 (1) | 0 (0) | 1 (20) | 4 (80) | 3 (60) | ||||
| Balanced | 2 | 0 | 0 | 2 | 1 | ||||
Patients may be counted more than once due to the coexistence of more than one cytogenetic abnormality in the leukemic clone. Percentages may not add to 100 because of rounding.
Balanced indicates the number of patients exhibiting a given abnormality in combination with t(8;21), t(11q23), t(15;17), or inv(16)/t(16;16); NA, not applicable.
Four cases detected only by FISH.
Six cases detected only by FISH.