Table 5. Episodes of grade 3-4 CNS... | American Society of Hematology

Table 5.

Episodes of grade 3-4 CNS toxicity

Phase	IT MTX, %	ITT, %
Consolidation/IM no. 1	1.0	0.9
DI no. 1	1.9	1.6
IM no. 2	0.2	0.3
DI no. 2*	0.9	2.1
Maintenance
Course 1	0.5	0.4
Courses 2-10†	1.3	1.4
Total	5.8	6.7

Phase	IT MTX, %	ITT, %
Consolidation/IM no. 1	1.0	0.9
DI no. 1	1.9	1.6
IM no. 2	0.2	0.3
DI no. 2*	0.9	2.1
Maintenance
Course 1	0.5	0.4
Courses 2-10†	1.3	1.4
Total	5.8	6.7

The total number of patients per phase ranged from 973 to 1018 for IT MTX and 969 to 1009 for ITT.

P = .025, χ²; all other comparisons are nonsignificant.

No girls after course 6.