Adverse events or laboratory abnormalities of grade 3 or 4 with frequency greater than 10% among all 102 patients treated
. | 15-mg arm, no. (%) . | . | . | 30-mg arm, no. (%) . | . | . | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| Toxicity type . | Grade 3 . | Grade 4 . | Grade 3/4 . | Grade 3 . | Grade 4 . | Grade 3/4 . | ||||
| Neutropenia | 20 (57) | 4 (11) | 24 (69) | 33 (49) | 8 (12) | 41 (61) | ||||
| Leukopenia | 12 (34) | 0 (0) | 12 (34) | 24 (36) | 1 (2) | 25 (37) | ||||
| Lymphopenia | 11 (31) | 3 (9) | 14 (40) | 21 (31) | 4 (6) | 25 (37) | ||||
| Thrombocytopenia | 9 (26) | 6 (17) | 15 (43) | 10 (15) | 11 (16) | 21 (31) | ||||
| Anemia | 4 (11) | 1 (3) | 5 (14) | 10 (15) | 1 (2) | 11 (16) | ||||
. | 15-mg arm, no. (%) . | . | . | 30-mg arm, no. (%) . | . | . | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| Toxicity type . | Grade 3 . | Grade 4 . | Grade 3/4 . | Grade 3 . | Grade 4 . | Grade 3/4 . | ||||
| Neutropenia | 20 (57) | 4 (11) | 24 (69) | 33 (49) | 8 (12) | 41 (61) | ||||
| Leukopenia | 12 (34) | 0 (0) | 12 (34) | 24 (36) | 1 (2) | 25 (37) | ||||
| Lymphopenia | 11 (31) | 3 (9) | 14 (40) | 21 (31) | 4 (6) | 25 (37) | ||||
| Thrombocytopenia | 9 (26) | 6 (17) | 15 (43) | 10 (15) | 11 (16) | 21 (31) | ||||
| Anemia | 4 (11) | 1 (3) | 5 (14) | 10 (15) | 1 (2) | 11 (16) | ||||
Thirty-five patients were treated on the 15-mg arm and 67 patients on the 30-mg arm