AID expression in EBV-infected cells in vivo
Case . | AID+/EBER+ (%) . | EBER+/AID+ (%) . | AID+/EBNA2+ (%) . | AID+/LMP1+ (%) . | EBNA2+/EBER+ (%) . | LMP1+/EBER+ (%) . |
|---|---|---|---|---|---|---|
| 1 | 83/573 (14.5) | 127/213 (59.6) | 7/258 (2.7) | 4/184 (2.1) | 714/1053 (67.8) | 120/1053 (11.4) |
| 2 | 83/1108 (7.5) | 171/253 (67.6) | 19/327 (5.8) | 15/159 (9.4) | 939/1496 (62.8) | 113/1496 (7.5) |
| 3 | 49/672 (7.3) | 191/261 (73.2) | 17/189 (9.0) | 18/230 (7.8) | 885/1177 (75.2) | 523/1177 (44.4) |
| 4 | 76/871 (8.7) | 171/247 (69.2) | 7/106 (6.6) | 15/170 (8.8) | 603/2004 (30.1) | 277/2004 (13.8) |
| 5 | 1/> 100 (< 1) | ND | NA | NA | NA | NA |
| 6 | 1/> 100 (< 1) | ND | NA | NA | NA | NA |
Case . | AID+/EBER+ (%) . | EBER+/AID+ (%) . | AID+/EBNA2+ (%) . | AID+/LMP1+ (%) . | EBNA2+/EBER+ (%) . | LMP1+/EBER+ (%) . |
|---|---|---|---|---|---|---|
| 1 | 83/573 (14.5) | 127/213 (59.6) | 7/258 (2.7) | 4/184 (2.1) | 714/1053 (67.8) | 120/1053 (11.4) |
| 2 | 83/1108 (7.5) | 171/253 (67.6) | 19/327 (5.8) | 15/159 (9.4) | 939/1496 (62.8) | 113/1496 (7.5) |
| 3 | 49/672 (7.3) | 191/261 (73.2) | 17/189 (9.0) | 18/230 (7.8) | 885/1177 (75.2) | 523/1177 (44.4) |
| 4 | 76/871 (8.7) | 171/247 (69.2) | 7/106 (6.6) | 15/170 (8.8) | 603/2004 (30.1) | 277/2004 (13.8) |
| 5 | 1/> 100 (< 1) | ND | NA | NA | NA | NA |
| 6 | 1/> 100 (< 1) | ND | NA | NA | NA | NA |
The frequency of AID-expressing cells among EBER-positive cells (AID+/EBER+) as well as among cells expressing EBNA2 (AID+/EBNA2+) or LMP1 (AID+/LMP1+) is given for tonsillar sections of infectious mononucleosis (cases 1-4) or hyperplastic tonsils from chronic virus carriers (cases 5-6). The EBER+/AID+ column indicates the frequency of EBER-positive cells among the indicated numbers of AID+ cells. To estimate the number of EBER+ cells that express EBNA2 (column 5) or LMP1 (column 6), sections were stained for either EBER, EBNA2, or LMP1, and positive cells were counted within an area of 0.62 mm2. ND indicates not done; NA, not applicable since no EBNA2+ or LMP1+ cells were detected.