Table 2.

Results of molecular studies in 20 children with ET, compared with 47 consecutive adult patients




V617Jak2

WTJak2

Total no.
No.
Major thrombotic complications
No.
Major thrombotic complications
Children      
   Girls*  15   —   —   —   —  
      Monoclonal   4   2   1 Budd Chiari   2   0  
      Polyclonal   10   0   0   10   0  
      Skewing   1   —   —   1   0  
   Boys   5   2   0   3   0  
   All children   20   4   1   16   0  
Adults      
   Women  36   20   —   16   —  
      Monoclonal   9   3   1 Budd Chiari; 1 cerebral vein   6   0  
      Polyclonal   11   7   1 Budd Chiari; 1 cerebral vein   4   0  
      Skewing   9   7   1 PA; 1 DVT   2   0  
      Homozygous   7   3   1 Budd Chiari   4   1 portal vein  
   Men   11   8   2 Budd Chiari; 1 MI   3   1 cerebral vein  
   All adults
 
47
 

 

 

 

 



V617Jak2

WTJak2

Total no.
No.
Major thrombotic complications
No.
Major thrombotic complications
Children      
   Girls*  15   —   —   —   —  
      Monoclonal   4   2   1 Budd Chiari   2   0  
      Polyclonal   10   0   0   10   0  
      Skewing   1   —   —   1   0  
   Boys   5   2   0   3   0  
   All children   20   4   1   16   0  
Adults      
   Women  36   20   —   16   —  
      Monoclonal   9   3   1 Budd Chiari; 1 cerebral vein   6   0  
      Polyclonal   11   7   1 Budd Chiari; 1 cerebral vein   4   0  
      Skewing   9   7   1 PA; 1 DVT   2   0  
      Homozygous   7   3   1 Budd Chiari   4   1 portal vein  
   Men   11   8   2 Budd Chiari; 1 MI   3   1 cerebral vein  
   All adults
 
47
 

 

 

 

 

WT indicates wild-type; PA, peripheral artery thrombosis; DVT, deep vein thrombosis; MI, myocardial infarction; and —, not applicable

*

Monoclonal cases made up 29% of informative cases; polyclonal cases, 71%

Monoclonal cases made up 45% of informative cases; polyclonal cases, 55%. Skewing cases made up 25% of all cases, while homozygous cases made up 19% of all cases

or Create an Account

Close Modal
Close Modal