Results of molecular studies in 20 children with ET, compared with 47 consecutive adult patients
. | . | V617Jak2 . | . | WTJak2 . | . | ||
|---|---|---|---|---|---|---|---|
. | Total no. . | No. . | Major thrombotic complications . | No. . | Major thrombotic complications . | ||
| Children | |||||||
| Girls* | 15 | — | — | — | — | ||
| Monoclonal | 4 | 2 | 1 Budd Chiari | 2 | 0 | ||
| Polyclonal | 10 | 0 | 0 | 10 | 0 | ||
| Skewing | 1 | — | — | 1 | 0 | ||
| Boys | 5 | 2 | 0 | 3 | 0 | ||
| All children | 20 | 4 | 1 | 16 | 0 | ||
| Adults | |||||||
| Women† | 36 | 20 | — | 16 | — | ||
| Monoclonal | 9 | 3 | 1 Budd Chiari; 1 cerebral vein | 6 | 0 | ||
| Polyclonal | 11 | 7 | 1 Budd Chiari; 1 cerebral vein | 4 | 0 | ||
| Skewing | 9 | 7 | 1 PA; 1 DVT | 2 | 0 | ||
| Homozygous | 7 | 3 | 1 Budd Chiari | 4 | 1 portal vein | ||
| Men | 11 | 8 | 2 Budd Chiari; 1 MI | 3 | 1 cerebral vein | ||
| All adults | 47 | — | — | — | — | ||
. | . | V617Jak2 . | . | WTJak2 . | . | ||
|---|---|---|---|---|---|---|---|
. | Total no. . | No. . | Major thrombotic complications . | No. . | Major thrombotic complications . | ||
| Children | |||||||
| Girls* | 15 | — | — | — | — | ||
| Monoclonal | 4 | 2 | 1 Budd Chiari | 2 | 0 | ||
| Polyclonal | 10 | 0 | 0 | 10 | 0 | ||
| Skewing | 1 | — | — | 1 | 0 | ||
| Boys | 5 | 2 | 0 | 3 | 0 | ||
| All children | 20 | 4 | 1 | 16 | 0 | ||
| Adults | |||||||
| Women† | 36 | 20 | — | 16 | — | ||
| Monoclonal | 9 | 3 | 1 Budd Chiari; 1 cerebral vein | 6 | 0 | ||
| Polyclonal | 11 | 7 | 1 Budd Chiari; 1 cerebral vein | 4 | 0 | ||
| Skewing | 9 | 7 | 1 PA; 1 DVT | 2 | 0 | ||
| Homozygous | 7 | 3 | 1 Budd Chiari | 4 | 1 portal vein | ||
| Men | 11 | 8 | 2 Budd Chiari; 1 MI | 3 | 1 cerebral vein | ||
| All adults | 47 | — | — | — | — | ||
WT indicates wild-type; PA, peripheral artery thrombosis; DVT, deep vein thrombosis; MI, myocardial infarction; and —, not applicable
Monoclonal cases made up 29% of informative cases; polyclonal cases, 71%
Monoclonal cases made up 45% of informative cases; polyclonal cases, 55%. Skewing cases made up 25% of all cases, while homozygous cases made up 19% of all cases