Hematologic responses to 3 different conditional signaling proteins
Response . | F36VFGFR1 . | F36VMpl . | V′ VJak2 . |
|---|---|---|---|
| In vitro | |||
| Sustained expansion in culture | + | + | - |
| Expansion of stHSCs | + | - | ND |
| Survival of ltHSCs | + | - | ND |
| In vivo | |||
| Red cells | +++ | ++ | + |
| Platelets | +++ | + | - |
| Granulocytes/monocytes | +++ | +/- | - |
Response . | F36VFGFR1 . | F36VMpl . | V′ VJak2 . |
|---|---|---|---|
| In vitro | |||
| Sustained expansion in culture | + | + | - |
| Expansion of stHSCs | + | - | ND |
| Survival of ltHSCs | + | - | ND |
| In vivo | |||
| Red cells | +++ | ++ | + |
| Platelets | +++ | + | - |
| Granulocytes/monocytes | +++ | +/- | - |
+ indicates present; -, absent; ND, not done; +++, strongest effect; ++, strong effect; +/-, variable and modest effect.