Cytogenetic abnormalities in V617F+ and V617F– patients with MPDs
. | V617F+ . | V617F– . | P . |
|---|---|---|---|
| Del(20q) total | 28 | 1 | < .001 |
| PV | 12 | 0 | |
| ET | 5 | 0 | |
| IMF | 10 | 1 | |
| MPD/MDS | 1 | 0 | |
| Del(13q) total | 3 | 9 | .17 |
| ET | 1 | 0 | |
| IMF | 2 | 9 | |
| Translocations total | 2 | 8 | .12 |
| ET | 0 | 4 | |
| IMF | 2 | 4 | |
| Trisomy 9 | 10 | 0 | .01 |
| PV | 3 | 0 | |
| ET | 3 | 0 | |
| IMF | 4 | 0 | |
| Trisomy 8 | 6 | 1 | .23 |
| PV | 2 | 0 | |
| ET | 2 | 0 | |
| IMF | 2 | 1 |
. | V617F+ . | V617F– . | P . |
|---|---|---|---|
| Del(20q) total | 28 | 1 | < .001 |
| PV | 12 | 0 | |
| ET | 5 | 0 | |
| IMF | 10 | 1 | |
| MPD/MDS | 1 | 0 | |
| Del(13q) total | 3 | 9 | .17 |
| ET | 1 | 0 | |
| IMF | 2 | 9 | |
| Translocations total | 2 | 8 | .12 |
| ET | 0 | 4 | |
| IMF | 2 | 4 | |
| Trisomy 9 | 10 | 0 | .01 |
| PV | 3 | 0 | |
| ET | 3 | 0 | |
| IMF | 4 | 0 | |
| Trisomy 8 | 6 | 1 | .23 |
| PV | 2 | 0 | |
| ET | 2 | 0 | |
| IMF | 2 | 1 |
Data are pooled from several sources, including 3 prospective ET trials (599 patients with cytogenetic results)11,12 , the European Myelofibrosis Network (71 patients)17 , the Addenbrooke MPD clinic (89 patients),1 and previous collaborative studies 20q and 13q deletions in MPDs21