Patient, donor, and graft characteristics
Variable . | HLA-identical sibling HCT . | Related mismatched HCT . | P . |
|---|---|---|---|
| Median age, y (range) | 37 (5-50) | 24 (3-50) | < .001 |
| Age 0 to 20 y, no. (%) | 8 (5) | 51 (38) | < .001 |
| Age 21 to 35 y, no. (%) | 65 (41) | 51 (38) | |
| Age older than 35 y, no. (%) | 85 (54) | 33 (24) | |
| Disease, no. (%) | .05 | ||
| CML | 68 (43) | 42 (31) | |
| AML | 39 (25) | 30 (22) | |
| ALL | 39 (25) | 53 (39) | |
| MDS | 12 (8) | 10 (7) | |
| Disease status, no. (%) | .07 | ||
| Early | 100 (63) | 68 (50) | |
| Intermediate | 33 (21) | 35 (26) | |
| Advanced | 25 (16) | 32 (24) | |
| Conditioning regimens, no. (%) | — | ||
| BUCY | 147 (93) | 0 (0) | |
| BUCY + ATG | 11 (7) | 135 (100) | |
| Donor-patient sex match, no. (%) | .38 | ||
| MM | 54 (34) | 37 (27) | |
| MF | 30 (19) | 21 (16) | |
| FM | 54 (34) | 55 (41) | |
| FF | 20 (13) | 22 (16) | |
| ABO match, no. (%) | .12 | ||
| Matched | 85 (54) | 68 (50) | |
| Minor mismatched | 23 (15) | 32 (24) | |
| Major mismatched | 50 (32) | 35 (26) | |
| Donor-patient relationship, no. (%) | — | ||
| Mother to child | 0 (0) | 60 (44) | |
| Father to child | 0 (0) | 21 (16) | |
| Child to parent | 0 (0) | 13 (10) | |
| Sibling | 158 (100) | 37 (27) | |
| Cousin | 0 (0) | 4 (3) | |
| Graft type, no. (%) | < .001 | ||
| BM + PB | 103 (65) | 130 (96) | |
| BM alone | 31 (20) | 4 (3) | |
| PB alone | 24 (15) | 1 (1) | |
| G-CSF use after HCT, no. (%) | 85 (54) | 132 (98) | < .001 |
| Median MNCs, × 108/kg (range) | 6.2 (2.3-13.6) | 7.5 (3.1-16.3) | < .001 |
| MNCs less than 7 × 108/kg, no. (%) | 106 (67) | 44 (33) | < .001 |
| MNCs 7 × 108/kg or more, no. (%) | 52 (33) | 91 (67) | |
| Median CD34+ count, × 106/kg (range)* | 2.4 (0.3-6.7) | 2.3 (0.2-9.7) | .79 |
| CD34+ count less than 2 × 106/kg, no. (%) | 46 (29) | 51 (38) | .14 |
| CD34+ count 2 × 106/kg or more, no. (%) | 90 (57) | 73 (54) | |
| CD34+ count NA, no. (%) | 22 (14) | 11 (8) | |
| Median CD3+ count, × 106/kg (range)† | 187 (9-676) | 177 (15-991) | .55 |
| CD3+ count less than 100 × 106/kg, no. (%) | 31 (20) | 12 (9) | .001 |
| CD3+ count 100 to 200 × 106/kg, no. (%) | 41 (26) | 63 (47) | |
| CD3+ count 200 × 106/kg or more, no. (%) | 63 (40) | 45 (33) | |
| CD3+ count NA, no. (%) | 23 (15) | 15 (11) | |
| Median CD4+ count, × 106/kg (range)† | 109 (5-489) | 98 (4-527) | .34 |
| CD4+ count less than 100 × 106/kg, no. (%) | 57 (36) | 62 (46) | .14 |
| CD4+ count 100 to 200 × 106/kg, no. (%) | 57 (36) | 49 (36) | |
| CD4+ count 200 × 106/kg or more, no. (%) | 21 (13) | 9 (7) | |
| CD4+ count NA, no. (%) | 23 (15) | 15 (11) | |
| Median CD8+, × 106/kg (range)† | 81 (4-382) | 76 (8-497) | .65 |
| CD8+ count less than 50 × 106/kg, no. (%) | 40 (25) | 33 (24) | .60 |
| CD8+ count 50 to 100 × 106/kg, no. (%) | 40 (25) | 43 (32) | |
| CD8+ count 100 × 106/kg or more, no. (%) | 55 (35) | 44 (33) | |
| CD8+ count NA, no. (%) | 23 (15) | 15 (11) | |
| Median follow-up time among living patients, mo (range)‡ | 17 (7-35) | 14 (6-35) | .01 |
Variable . | HLA-identical sibling HCT . | Related mismatched HCT . | P . |
|---|---|---|---|
| Median age, y (range) | 37 (5-50) | 24 (3-50) | < .001 |
| Age 0 to 20 y, no. (%) | 8 (5) | 51 (38) | < .001 |
| Age 21 to 35 y, no. (%) | 65 (41) | 51 (38) | |
| Age older than 35 y, no. (%) | 85 (54) | 33 (24) | |
| Disease, no. (%) | .05 | ||
| CML | 68 (43) | 42 (31) | |
| AML | 39 (25) | 30 (22) | |
| ALL | 39 (25) | 53 (39) | |
| MDS | 12 (8) | 10 (7) | |
| Disease status, no. (%) | .07 | ||
| Early | 100 (63) | 68 (50) | |
| Intermediate | 33 (21) | 35 (26) | |
| Advanced | 25 (16) | 32 (24) | |
| Conditioning regimens, no. (%) | — | ||
| BUCY | 147 (93) | 0 (0) | |
| BUCY + ATG | 11 (7) | 135 (100) | |
| Donor-patient sex match, no. (%) | .38 | ||
| MM | 54 (34) | 37 (27) | |
| MF | 30 (19) | 21 (16) | |
| FM | 54 (34) | 55 (41) | |
| FF | 20 (13) | 22 (16) | |
| ABO match, no. (%) | .12 | ||
| Matched | 85 (54) | 68 (50) | |
| Minor mismatched | 23 (15) | 32 (24) | |
| Major mismatched | 50 (32) | 35 (26) | |
| Donor-patient relationship, no. (%) | — | ||
| Mother to child | 0 (0) | 60 (44) | |
| Father to child | 0 (0) | 21 (16) | |
| Child to parent | 0 (0) | 13 (10) | |
| Sibling | 158 (100) | 37 (27) | |
| Cousin | 0 (0) | 4 (3) | |
| Graft type, no. (%) | < .001 | ||
| BM + PB | 103 (65) | 130 (96) | |
| BM alone | 31 (20) | 4 (3) | |
| PB alone | 24 (15) | 1 (1) | |
| G-CSF use after HCT, no. (%) | 85 (54) | 132 (98) | < .001 |
| Median MNCs, × 108/kg (range) | 6.2 (2.3-13.6) | 7.5 (3.1-16.3) | < .001 |
| MNCs less than 7 × 108/kg, no. (%) | 106 (67) | 44 (33) | < .001 |
| MNCs 7 × 108/kg or more, no. (%) | 52 (33) | 91 (67) | |
| Median CD34+ count, × 106/kg (range)* | 2.4 (0.3-6.7) | 2.3 (0.2-9.7) | .79 |
| CD34+ count less than 2 × 106/kg, no. (%) | 46 (29) | 51 (38) | .14 |
| CD34+ count 2 × 106/kg or more, no. (%) | 90 (57) | 73 (54) | |
| CD34+ count NA, no. (%) | 22 (14) | 11 (8) | |
| Median CD3+ count, × 106/kg (range)† | 187 (9-676) | 177 (15-991) | .55 |
| CD3+ count less than 100 × 106/kg, no. (%) | 31 (20) | 12 (9) | .001 |
| CD3+ count 100 to 200 × 106/kg, no. (%) | 41 (26) | 63 (47) | |
| CD3+ count 200 × 106/kg or more, no. (%) | 63 (40) | 45 (33) | |
| CD3+ count NA, no. (%) | 23 (15) | 15 (11) | |
| Median CD4+ count, × 106/kg (range)† | 109 (5-489) | 98 (4-527) | .34 |
| CD4+ count less than 100 × 106/kg, no. (%) | 57 (36) | 62 (46) | .14 |
| CD4+ count 100 to 200 × 106/kg, no. (%) | 57 (36) | 49 (36) | |
| CD4+ count 200 × 106/kg or more, no. (%) | 21 (13) | 9 (7) | |
| CD4+ count NA, no. (%) | 23 (15) | 15 (11) | |
| Median CD8+, × 106/kg (range)† | 81 (4-382) | 76 (8-497) | .65 |
| CD8+ count less than 50 × 106/kg, no. (%) | 40 (25) | 33 (24) | .60 |
| CD8+ count 50 to 100 × 106/kg, no. (%) | 40 (25) | 43 (32) | |
| CD8+ count 100 × 106/kg or more, no. (%) | 55 (35) | 44 (33) | |
| CD8+ count NA, no. (%) | 23 (15) | 15 (11) | |
| Median follow-up time among living patients, mo (range)‡ | 17 (7-35) | 14 (6-35) | .01 |
Except where otherwise noted, n = 158 for HLA-identical sibling donors, and n = 135 for related mismatched donors.
NA indicates that data were not available; —, data not comparable.
n = 136 for HLA-identical sibling donors, and n = 124 for related mismatched donors.
n = 135 for HLA-identical sibling donors, and n = 120 for related mismatched donors.
n = 119 for HLA-identical sibling donors, and n = 94 for related mismatched donors.