Table 3.

Summary of tandutinib dose escalation

Dose level, mg twice daily
No. of patients
No. of patients with DLTs
No. of patients with FLT3-ITD
50   6   0   0  
100   3   0   0  
150   6   1   1  
200   3   0   0  
250   3   0   0  
300   6   1   1  
400   4   0   1  
525   6   1   3  
700   3   3   2  
Total
 		 40
 		 6
 		 8
 
Dose level, mg twice daily
No. of patients
No. of patients with DLTs
No. of patients with FLT3-ITD
50   6   0   0  
100   3   0   0  
150   6   1   1  
200   3   0   0  
250   3   0   0  
300   6   1   1  
400   4   0   1  
525   6   1   3  
700   3   3   2  
Total
 		 40
 		 6
 		 8
 
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