Patients with FLT3 mutations
Patient no. . | Tandutinib dose level, mg twice daily . | FLT3 mutation . | Hemizygous or homozygous . |
|---|---|---|---|
| 24 | 150 | 9 AA ITD after D600 | Yes |
| 52 | 300 | 13 AA ITD after D600 | No |
| 62 | 400* | 33 AA ITD after F612 | No |
| 64 | 400 | D835Y | No |
| 73 | 525 | 20 AA ITD after F612 | No |
| 74 | 525 | 58 AA ITD after F612 | No |
| 76 | 525 | 38 AA ITD after F612 | Yes |
| 82 | 700 | 7 AA ITD after D600 | Yes |
| 83 | 700 | 19 AA ITD after E608 | Yes |
Patient no. . | Tandutinib dose level, mg twice daily . | FLT3 mutation . | Hemizygous or homozygous . |
|---|---|---|---|
| 24 | 150 | 9 AA ITD after D600 | Yes |
| 52 | 300 | 13 AA ITD after D600 | No |
| 62 | 400* | 33 AA ITD after F612 | No |
| 64 | 400 | D835Y | No |
| 73 | 525 | 20 AA ITD after F612 | No |
| 74 | 525 | 58 AA ITD after F612 | No |
| 76 | 525 | 38 AA ITD after F612 | Yes |
| 82 | 700 | 7 AA ITD after D600 | Yes |
| 83 | 700 | 19 AA ITD after E608 | Yes |
Patient received only 1 dose of tandutinib.