In vivo recovery (chromogenic method)
. | In vivo recovery for each dosing cohort . | . | |
|---|---|---|---|
| Treatment . | 35 IU/kg . | 25 IU/kg . | |
| Segment 1, rFVIII | |||
| n | 11 | 12 | |
| Mean, IU/dL per IU/kg | 2.7 | 2.1 | |
| Standard error, IU/dL per IU/kg | 0.6 | 0.7 | |
| Median, IU/dL per IU/kg | 2.7 | 2.1 | |
| Segment 2, PEGLip rFVIII, infusion 1 | |||
| n | 11 | 12 | |
| Estimate, IU/dL per IU/kg | 3.1 | 2.1 | |
| Standard error, IU/dL per IU/kg | 0.7 | 0.3 | |
| Median, IU/dL per IU/kg | 2.8 | 2.1 | |
| Segment 3, PEGLip rFVIII, infusion 2 | |||
| n | 10 | 10 | |
| Estimate, IU/dL per IU/kg | 3.0 | 2.2 | |
| Standard error, IU/dL per IU/kg | 0.6 | 0.6 | |
| Median, IU/dL per IU/kg | 2.9 | 2.2 | |
. | In vivo recovery for each dosing cohort . | . | |
|---|---|---|---|
| Treatment . | 35 IU/kg . | 25 IU/kg . | |
| Segment 1, rFVIII | |||
| n | 11 | 12 | |
| Mean, IU/dL per IU/kg | 2.7 | 2.1 | |
| Standard error, IU/dL per IU/kg | 0.6 | 0.7 | |
| Median, IU/dL per IU/kg | 2.7 | 2.1 | |
| Segment 2, PEGLip rFVIII, infusion 1 | |||
| n | 11 | 12 | |
| Estimate, IU/dL per IU/kg | 3.1 | 2.1 | |
| Standard error, IU/dL per IU/kg | 0.7 | 0.3 | |
| Median, IU/dL per IU/kg | 2.8 | 2.1 | |
| Segment 3, PEGLip rFVIII, infusion 2 | |||
| n | 10 | 10 | |
| Estimate, IU/dL per IU/kg | 3.0 | 2.2 | |
| Standard error, IU/dL per IU/kg | 0.6 | 0.6 | |
| Median, IU/dL per IU/kg | 2.9 | 2.2 | |