Baseline factors predictive of the response at d80 (logistic regression analysis) and of overall survival (Cox proportional hazards model)
Category pair for each baseline variable . | N . | ORP* . | Odds ratio (95% CI) . | OSP* . | Hazard ratio (95% CI) . |
|---|---|---|---|---|---|
| 48 y or younger/older than 48 y | 19/24 | .390 | 0.583 (0.171; 1.993) | .665 | 1.248 (0.459; 3.392) |
| Female/male | 11/32 | .922 | 1.072 (0.270; 4.247) | .838 | 1.123 (0.368; 3.429) |
| Performance status (ECOG) less than 2/ECOG 2 or higher | 29/14 | .158 | 2.679 (0.681; 10.534) | .113 | 2.276 (0.823; 6.290) |
| Time from transplantation to PTLD diagnosis, 1 y or less/more than 1 y | 14/29 | .439 | 0.595 (0.160; 2.214) | .584 | 1.318 (0.490; 3.542) |
| No. sites, 1/more than 1 | 14/29 | .238 | 2.182 (0.596; 7.984) | .035 | 3.821 (1.096; 13.326) |
| Histologic type, monomorphic/polymorphic† | 28/4 | .208 | 0.216 (0.020; 2.347) | .383 | 2.476 (0.323; 19.0) |
| Cell EBV viral load, 600 copies/μg DNA or less/more than 600 copies/μg DNA‡ | 21/18 | .167 | 0.400 (0.109; 1.466) | .666 | 1.238 (0.470; 3.259) |
| Lactate dehydrogenase, normal/abnormal | 15/28 | .007 | 6.875 (1.682; 28.10) | .119 | 2.313 (0.807; 6.631) |
Category pair for each baseline variable . | N . | ORP* . | Odds ratio (95% CI) . | OSP* . | Hazard ratio (95% CI) . |
|---|---|---|---|---|---|
| 48 y or younger/older than 48 y | 19/24 | .390 | 0.583 (0.171; 1.993) | .665 | 1.248 (0.459; 3.392) |
| Female/male | 11/32 | .922 | 1.072 (0.270; 4.247) | .838 | 1.123 (0.368; 3.429) |
| Performance status (ECOG) less than 2/ECOG 2 or higher | 29/14 | .158 | 2.679 (0.681; 10.534) | .113 | 2.276 (0.823; 6.290) |
| Time from transplantation to PTLD diagnosis, 1 y or less/more than 1 y | 14/29 | .439 | 0.595 (0.160; 2.214) | .584 | 1.318 (0.490; 3.542) |
| No. sites, 1/more than 1 | 14/29 | .238 | 2.182 (0.596; 7.984) | .035 | 3.821 (1.096; 13.326) |
| Histologic type, monomorphic/polymorphic† | 28/4 | .208 | 0.216 (0.020; 2.347) | .383 | 2.476 (0.323; 19.0) |
| Cell EBV viral load, 600 copies/μg DNA or less/more than 600 copies/μg DNA‡ | 21/18 | .167 | 0.400 (0.109; 1.466) | .666 | 1.238 (0.470; 3.259) |
| Lactate dehydrogenase, normal/abnormal | 15/28 | .007 | 6.875 (1.682; 28.10) | .119 | 2.313 (0.807; 6.631) |